Effects of cholera toxin on the gut's nervous system

Grant number: 1006453 | Funding period: 2011 - 2014

Completed

Abstract

Many bacteria that cause diarrhoea act via the gut’s own nervous system to massively increase the transport of water and salt into the lumen of the intestine. In this project we will investigate mechanisms that lead to this over-excitation of the gut’s nervous system to test the idea that this is due to a change in the properties of the final nerve cells in the normal pathway that controls water transport. This will identify novel sites for drug treatments of diarrhoea.

Related publications (8)

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Nitric Oxide Regulates Estrus Cycle Dependent Colonic Motility in Mice

Gayathri K Balasuriya, Saseema S Nugapitiya, Elisa L Hill-Yardin, Joel C Bornstein

2021-09-29

Women are more susceptible to functional bowel disorders than men and the severity of their symptoms such as diarrhea, constipatio..

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Cholinergic Submucosal Neurons Display Increased Excitability Following in Vivo Cholera Toxin Exposure in Mouse Ileum

Candice Fung, Katerina Koussoulas, Petra Unterweger, Andrew M Allen, Joel C Bornstein, Jaime PP Foong

2018-03-21

Cholera-induced hypersecretion causes dehydration and death if untreated. Cholera toxin (CT) partly acts via the enteric nervous s..

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Cholera Toxin Induces Sustained Hyperexcitability in Myenteric, but Not Submucosal, AH Neurons in Guinea Pig Jejunum

Katerina Koussoulas, Rachel M Gwynne, Jaime PP Foong, Joel C Bornstein

2017-04-27

Background and Aims: Cholera toxin (CT)-induced hypersecretion requires activation of secretomotor pathways in the enteric nervous..

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A sexually dimorphic effect of cholera toxin: rapid changes in colonic motility mediated via a 5-HT3 receptor-dependent pathway in female C57Bl/6 mice

Gayathri K Balasuriya, Elisa L Hill-Yardin, Michael D Gershon, Joel C Bornstein

2016-08-01

KEY POINTS: Cholera causes more than 100,000 deaths each year as a result of severe diarrhoea, vomiting and dehydration due to the..

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VPAC(1) receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum

Candice Fung, Petra Unterweger, Laura J Parry, Joel C Bornstein, Jaime PP Foong

2014-05-01

In the gastrointestinal tract, vasoactive intestinal peptide (VIP) is found exclusively within neurons. VIP regulates intestinal m..

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Properties of cholinergic and non-cholinergic submucosal neurons along the mouse colon

Jaime Pei Pei Foong, Iain R Tough, Helen M Cox, Joel C Bornstein

2014-02-15

Submucosal neurons are vital regulators of water and electrolyte secretion and local blood flow in the gut. Due to the availabilit..

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The emergence of neural activity and its role in the development of the enteric nervous system

Marlene M Hao, Joel C Bornstein, Pieter Vanden Berghe, Alan E Lomax, Heather M Young, Jaime PP Foong

2013-10-01

The enteric nervous system (ENS) is a vital part of the autonomic nervous system that regulates many gastrointestinal functions, i..

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Serotonin in the gut: what does it do?

Joel C Bornstein

2012-01-01

University of Melbourne Researchers