Effects of cholera toxin on the gut's nervous system
Grant number: 1006453 | Funding period: 2011 - 2014
Many bacteria that cause diarrhoea act via the gut’s own nervous system to massively increase the transport of water and salt into the lumen of the intestine. In this project we will investigate mechanisms that lead to this over-excitation of the gut’s nervous system to test the idea that this is due to a change in the properties of the final nerve cells in the normal pathway that controls water transport. This will identify novel sites for drug treatments of diarrhoea.
Related publications (8)
Cholinergic Submucosal Neurons Display Increased Excitability Following in Vivo Cholera Toxin Exposure in Mouse Ileum
Candice Fung, Katerina Koussoulas, Petra Unterweger, Andrew M Allen, Joel C Bornstein, Jaime PP Foong
Cholera-induced hypersecretion causes dehydration and death if untreated. Cholera toxin (CT) partly acts via the enteric nervous s..
Cholera Toxin Induces Sustained Hyperexcitability in Myenteric, but Not Submucosal, AH Neurons in Guinea Pig Jejunum
Katerina Koussoulas, Rachel M Gwynne, Jaime PP Foong, Joel C Bornstein
Background and Aims: Cholera toxin (CT)-induced hypersecretion requires activation of secretomotor pathways in the enteric nervous..
A sexually dimorphic effect of cholera toxin: rapid changes in colonic motility mediated via a 5-HT3 receptor-dependent pathway in female C57Bl/6 mice
Gayathri K Balasuriya, Elisa L Hill-Yardin, Michael D Gershon, Joel C Bornstein
KEY POINTS: Cholera causes more than 100,000 deaths each year as a result of severe diarrhoea, vomiting and dehydration due to the..
VPAC(1) receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum
Candice Fung, Petra Unterweger, Laura J Parry, Joel C Bornstein, Jaime PP Foong
In the gastrointestinal tract, vasoactive intestinal peptide (VIP) is found exclusively within neurons. VIP regulates intestinal m..
The emergence of neural activity and its role in the development of the enteric nervous system
Marlene M Hao, Joel C Bornstein, Pieter Vanden Berghe, Alan E Lomax, Heather M Young, Jaime PP Foong
The enteric nervous system (ENS) is a vital part of the autonomic nervous system that regulates many gastrointestinal functions, i..