Tracking the development of Alzheimer's disease with beta amyloid imaging
Grant number: 1011689 | Funding period: 2011 - 2013
A new scan called PiB PET shows the build up of amyloid protein deposits in the brain in all patients with Alzheimer's disease (AD) but also in 30% of normal elderly persons. This study will track the build up of amyloid and clinical progress in 280 elderly Australians to confirm that this scan can detect AD before symptoms and investigate factors that influence this build up and its damaging effects on memory and thinking. Early detection of Alzheimer's disease will assist accurate diagnosis and the development of treatment.
Related publications (7)
Comparison of F-18-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL (R) approaches: Validation against histopathology
Vincent Dore, Santiago Bullich, Christopher C Rowe, Pierrick Bourgeat, Salamata Konate, Osama Sabri, Andrew W Stephens, Henryk Barthel, Jurgen Fripp, Colin L Masters, Ludger Dinkelborg, Olivier Salvado, Victor L Villemagne, Susan De Santi
Predicting Alzheimer Disease with beta-Amyloid Imaging: Results from the Australian Imaging, Biomarkers, and Lifestyle Study of Ageing
Christopher C Rowe, Pierrick Bourgeat, Kathryn A Ellis, Belinda Brown, Yen Ying Lim, Rachel Mulligan, Gareth Jones, Paul Maruff, Michael Woodward, Roger Price, Peter Robins, Henri Tochon-Danguy, Graeme O'Keefe, Kerryn E Pike, Paul Yates, Cassandra Szoeke, Olivier Salvado, S Lance Macaulay, Timothy O'Meara, Richard Head