Vasomotor Ganglionic Transmission: The Preganglionic Peptide And The Second Gear

Grant number: 1010907 | Funding period: 2011 - 2013

Completed

Abstract

Blood pressure depends on nerve signals that travel from the central nervous system to blood vessels. In the middle of this pathway is a relay station - the sympathetic ganglion cell. Transmission through this relay station has recently been shown to have not only a fixed but also a variable component - the 'second gear'. The project tests if and how three likely candidate peptide molecules, one in the nerves, two in the bloodstream, control this 'second gear' and hence regulate blood pressure.