Understanding how proteoglycans in the placenta cause restriction of fetal growth

Grant number: 1004952 | Funding period: 2011 - 2013

Completed

Abstract

Fetal growth restriction (FGR) is a pregnancy complication in which the baby doesn�t grow properly in the womb. Growth restricted babies are much more likely to be stillborn. These babies are also at risk of problems later in life such as obesity, diabetes and heart disease. This study investigates molecules in the placenta that may be responsible for causing FGR. If we can understand how these molecules cause the problem of FGR, we may be able to find better ways of treating or preventing it.

Related publications (4)

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Decreased placental glypican expression is associated with human fetal growth restriction

T Gunatillake, A Chui, E Fitzpatrick, V Ignjatovic, P Monagle, J Whitelock, D Zanten, J Eijsink, A Borg, J Stevenson, SP Brennecke, JJHM Erwich, JM Said, P Murthi

2019-01-15

Placental mediated fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Heparan sulphate proteo..

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Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells

Amy Chui, Tilini Gunatillake, Shaun P Brennecke, Vera Ignjatovic, Paul T Monagle, John M Whitelock, Dagmar E van Zanten, Jasper Eijsink, Yao Wang, James Deane, Anthony J Borg, Janet Stevenson, Jan Jaap Erwich, Joanne M Said, Padma Murthi

2017-06-01

OBJECTIVE: Biglycan (BGN) has reduced expression in placentae from pregnancies complicated by fetal growth restriction (FGR). We u..

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Decorin expression is decreased in first trimester placental tissue from pregnancies with small for gestation age infants at birth

P Murthi, DE van Zanten, JJH Eijsink, AJ Borg, JL Stevenson, B Kalionis, AK Chui, JM Said, SP Brennecke, JJHM Emrich

2016-09-01

Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. FGR pregnancies are often associated with ..

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Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?

A Chui, P Murthi, T Gunatillake, SP Brennecke, V Ignjatovic, PT Monagle, JM Whitelock, JM Said

2014-08-01

OBJECTIVE: Fetal growth restriction (FGR) is a key cause of adverse pregnancy outcome where maternal and fetal factors are identif..