The cardovascular actions of compounds acting at the ghrelin

Grant number: 1005811 | Funding period: 2011 - 2014

Completed

Abstract

Ghrelin is a hormone that is known to control food intake and growth hormone release. Our recent work shows that compounds that mimic ghrelin�s actions influence blood pressure by their effects in the brain, the spinal cord and on arteries. We will investigate the potential of such compounds to treat blood pressure disorders

Related publications (8)

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Site and mechanism of the colokinetic action of the ghrelin receptor agonist, HM01

K Naitou, TP Mamerto, RV Pustovit, B Callaghan, LR Rivera, AJ Chan, MT Ringuet, C Pietra, JB Furness

2015-12-01

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Analysis of the ghrelin receptor-independent vascular actions of ulimorelin

John Broad, Brid Callaghan, Gareth J Sanger, James A Brock, John B Furness

2015-04-05

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Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor

Brid Callaghan, Samin Kosari, Ruslan V Pustovit, Daniela M Sartor, Dorota Ferens, Kung Ban, Jonathan Baell, Trung V Nguyen, Leni R Rivera, James A Brock, John B Furness

2014-03-01

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The mechanism of enhanced defecation caused by the ghrelin receptor agonist, ulimorelin

RV Pustovit, B Callaghan, S Kosari, LR Rivera, H Thomas, JA Brock, JB Furness

2014-02-01

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Sites of action of ghrelin receptor ligands in cardiovascular control

Brid Callaghan, Billie Hunne, Haruko Hirayama, Daniela M Sartor, Trung V Nguyen, Fe C Abogadie, Dorota Ferens, Peter McIntyre, Kung Ban, Jonathan Baell, John B Furness, James A Brock

2012-10-01

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Identification of neurons that express ghrelin receptors in autonomic pathways originating from the spinal cord

John B Furness, Hyun-Jung Cho, Billie Hunne, Haruko Hirayama, Brid P Callaghan, Alan E Lomax, James A Brock

2012-06-01

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INVESTIGATION OF THE PRESENCE OF GHRELIN IN THE CENTRAL NERVOUS SYSTEM OF THE RAT AND MOUSE

JB Furness, B Hunne, N Matsuda, L Yin, D Russo, I Kato, M Fujimiya, M Patterson, J McLeod, ZB Andrews, R Bron

2011-10-13

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Ghrelin receptors are expressed by distal tubules of the mouse kidney

Gene Venables, Billie Hunne, Romke Bron, Hyun-Jung Cho, James A Brock, John B Furness

2011-10-01