The cardovascular actions of compounds acting at the ghrelin

A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy

Ian A Parish, Lincon A Stamp, Ayla May D Lorenzo, Suzanne M Fowler, Yovina Sontani, Lisa A Miosge, Debbie R Howard, Christopher C Goodnow, Heather M Young, John B Furness

2016-09-01

Chronic intestinal pseudo-obstruction (CIPO) is a rare but life-threatening disease characterized by severe intestinal dysmotility..

Site and mechanism of the colokinetic action of the ghrelin receptor agonist, HM01

K Naitou, TP Mamerto, RV Pustovit, B Callaghan, LR Rivera, AJ Chan, MT Ringuet, C Pietra, JB Furness

2015-12-01

BACKGROUND: It has been recently demonstrated that the ghrelin receptor agonist, HM01, caused defecation in rats that were treated..

Analysis of the ghrelin receptor-independent vascular actions of ulimorelin

John Broad, Brid Callaghan, Gareth J Sanger, James A Brock, John B Furness

2015-04-05

Ulimorelin (TZP101) is a ghrelin receptor agonist that stimulates intestinal motility, but also reduces blood pressure in rodents ..

Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor

Brid Callaghan, Samin Kosari, Ruslan V Pustovit, Daniela M Sartor, Dorota Ferens, Kung Ban, Jonathan Baell, Trung V Nguyen, Leni R Rivera, James A Brock, John B Furness

2014-03-01

BACKGROUND AND PURPOSE: Some agonists of ghrelin receptors cause rapid decreases in BP. The mechanisms by which they cause hypoten..

The mechanism of enhanced defecation caused by the ghrelin receptor agonist, ulimorelin

RV Pustovit, B Callaghan, S Kosari, LR Rivera, H Thomas, JA Brock, JB Furness

2014-02-01

BACKGROUND: Discovery of adequate pharmacological treatments for constipation has proven elusive. Increased numbers of bowel movem..

Sites of action of ghrelin receptor ligands in cardiovascular control

Brid Callaghan, Billie Hunne, Haruko Hirayama, Daniela M Sartor, Trung V Nguyen, Fe C Abogadie, Dorota Ferens, Peter McIntyre, Kung Ban, Jonathan Baell, John B Furness, James A Brock

2012-10-01

Circulating ghrelin reduces blood pressure, but the mechanism for this action is unknown. This study investigated whether ghrelin ..

Identification of neurons that express ghrelin receptors in autonomic pathways originating from the spinal cord

John B Furness, Hyun-Jung Cho, Billie Hunne, Haruko Hirayama, Brid P Callaghan, Alan E Lomax, James A Brock

2012-06-01

Functional studies have shown that subsets of autonomic preganglionic neurons respond to ghrelin and ghrelin mimetics and in situ ..

INVESTIGATION OF THE PRESENCE OF GHRELIN IN THE CENTRAL NERVOUS SYSTEM OF THE RAT AND MOUSE

JB Furness, B Hunne, N Matsuda, L Yin, D Russo, I Kato, M Fujimiya, M Patterson, J McLeod, ZB Andrews, R Bron

2011-10-13

Ghrelin and ghrelin receptor agonist have effects on central neurons in many locations, including the hypothalamus, caudal brain s..

Ghrelin receptors are expressed by distal tubules of the mouse kidney

Gene Venables, Billie Hunne, Romke Bron, Hyun-Jung Cho, James A Brock, John B Furness

2011-10-01

Ghrelin, a peptide hormone from the stomach, has been recently discovered to reduce sodium excretion from the kidney. Although the..