The cardovascular actions of compounds acting at the ghrelin
Grant number: 1005811 | Funding period: 2011 - 2014
Ghrelin is a hormone that is known to control food intake and growth hormone release. Our recent work shows that compounds that mimic ghrelin�s actions influence blood pressure by their effects in the brain, the spinal cord and on arteries. We will investigate the potential of such compounds to treat blood pressure disorders
Related publications (9)
A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy
Ian A Parish, Lincon A Stamp, Ayla May D Lorenzo, Suzanne M Fowler, Yovina Sontani, Lisa A Miosge, Debbie R Howard, Christopher C Goodnow, Heather M Young, John B Furness
Chronic intestinal pseudo-obstruction (CIPO) is a rare but life-threatening disease characterized by severe intestinal dysmotility..
Site and mechanism of the colokinetic action of the ghrelin receptor agonist, HM01
K Naitou, TP Mamerto, RV Pustovit, B Callaghan, LR Rivera, AJ Chan, MT Ringuet, C Pietra, JB Furness
BACKGROUND: It has been recently demonstrated that the ghrelin receptor agonist, HM01, caused defecation in rats that were treated..
Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor
Brid Callaghan, Samin Kosari, Ruslan V Pustovit, Daniela M Sartor, Dorota Ferens, Kung Ban, Jonathan Baell, Trung V Nguyen, Leni R Rivera, James A Brock, John B Furness
BACKGROUND AND PURPOSE: Some agonists of ghrelin receptors cause rapid decreases in BP. The mechanisms by which they cause hypoten..
The mechanism of enhanced defecation caused by the ghrelin receptor agonist, ulimorelin
RV Pustovit, B Callaghan, S Kosari, LR Rivera, H Thomas, JA Brock, JB Furness
BACKGROUND: Discovery of adequate pharmacological treatments for constipation has proven elusive. Increased numbers of bowel movem..
Sites of action of ghrelin receptor ligands in cardiovascular control
Brid Callaghan, Billie Hunne, Haruko Hirayama, Daniela M Sartor, Trung V Nguyen, Fe C Abogadie, Dorota Ferens, Peter McIntyre, Kung Ban, Jonathan Baell, John B Furness, James A Brock
Circulating ghrelin reduces blood pressure, but the mechanism for this action is unknown. This study investigated whether ghrelin ..
Identification of neurons that express ghrelin receptors in autonomic pathways originating from the spinal cord
John B Furness, Hyun-Jung Cho, Billie Hunne, Haruko Hirayama, Brid P Callaghan, Alan E Lomax, James A Brock
Functional studies have shown that subsets of autonomic preganglionic neurons respond to ghrelin and ghrelin mimetics and in situ ..
INVESTIGATION OF THE PRESENCE OF GHRELIN IN THE CENTRAL NERVOUS SYSTEM OF THE RAT AND MOUSE
JB Furness, B Hunne, N Matsuda, L Yin, D Russo, I Kato, M Fujimiya, M Patterson, J McLeod, ZB Andrews, R Bron
Ghrelin and ghrelin receptor agonist have effects on central neurons in many locations, including the hypothalamus, caudal brain s..