Neural networks and transmitters controlling behavioural state and cognition
Grant number: 1005988 | Funding period: 2011 - 2013
Mental illness and dementia are significant social and economic burdens worldwide and knowledge of their underlying causes and more effective therapies are required. Our research aims to use pre-clinical models to characterize a little studied neuronal network implicated in control of brain theta rhythm activity, which could lead to improved treatment of neuropsychiatric diseases such as anxiety and depression, and degenerative cognitive decline.
Related publications (12)
Analysis of morphological and neurochemical changes in subthalamic nucleus neurons in response to a unilateral 6-OHDA lesion of the substantia nigra in adult rats
Katayoun Sedaghat, Andrew L Gundlach, David Finkelstein
Background: Subthalamic nucleus (STN) neurons undergo changes in their pattern of activity and morphology during the clinical cour..
Chronic activation of the relaxin-3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance
Valeria Rytova, Despina E Ganella, David Hawkes, Ross AD Bathgate, Sherie Ma, Andrew L Gundlach
Anxiety disorders are highly prevalent in modern society and better treatments are required. Key brain areas and signaling systems..
Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders
Jigna Rajesh Kumar, Ramamoorthy Rajkumar, Tharindunee Jayakody, Subhi Marwari, Jia Mei Hong, Sherie Ma, Andrew L Gundlach, Mitchell KP Lai, Gavin S Dawe
Relaxin-3 has been proposed to modulate emotional-behavioural functions such as arousal and behavioural activation, appetite regul..
Nucleus incertus promotes cortical desynchronization and behavioral arousal
Sherie Ma, Giancarlo Allocca, Emma KE Ong-Palsson, Caitlin E Singleton, David Hawkes, Stuart J McDougall, Spencer J Williams, Ross AD Bathgate, Andrew L Gundlach
Arousal and vigilance are essential for survival and relevant regulatory neural circuits lie within the brainstem, hypothalamus an..
Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala
Fabio N Santos, Celia W Pereira, Ana M Sanchez-Perez, Marcos Otero-Garcia, Sherie Ma, Andrew L Gundlach, Francisco E Olucha-Bordonau
The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerfu..
Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3/RXFP3 Deficiency
Mouna Haidar, Monica Lam, Berenice E Chua, Craig M Smith, Andrew L Gundlach
Methamphetamine (METH) is a highly addictive psychostimulant, and cessation of use is associated with reduced monoamine signalling..
ANXIOGENIC DRUG ADMINISTRATION AND ELEVATED PLUS-MAZE EXPOSURE IN RATS ACTIVATE POPULATIONS OF RELAXIN-3 NEURONS IN THE NUCLEUS INCERTUS AND SEROTONERGIC NEURONS IN THE DORSAL RAPHE NUCLEUS
AJ Lawther, ML Clissold, S Ma, S Kent, CA Lowry, AL Gundlach, MW Hale
Anxiety is a complex and adaptive emotional state controlled by a distributed and interconnected network of brain regions, and dis..
Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuro psychiatric diseases?
Craig M Smith, Andrew W Walker, Ihaia T Hosken, Berenice E Chua, Cary Zhang, Mouna Haidar, Andrew L Gundlach
Animal and clinical studies of gene-environment interactions have helped elucidate the mechanisms involved in the pathophysiology ..
Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus
DE Ganella, GE Callander, S Ma, CR Bye, AL Gundlach, RAD Bathgate
Relaxin-3 is a neuropeptide that is abundantly expressed by discrete brainstem neuron populations that broadly innervate forebrain..
Chemical synthesis and orexigenic activity of rat/mouse relaxin-3
Mohammed Akhter Hossain, Craig M Smith, Philip J Ryan, Elena Buechler, Ross AD Bathgate, Andrew L Gundlach, John D Wade
The insulin-like peptide, relaxin-3 was first identified just a decade ago via a genomic database search and is now recognized to ..
Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies
Anna Blasiak, Tomasz Blasiak, Marian H Lewandowski, Mohammed Akhter Hossain, John D Wade, Andrew L Gundlach
Behavioural state is controlled by a range of neural systems that are sensitive to internal and external stimuli. The relaxin-3 an..
Silencing Relaxin-3 in Nucleus Incertus of Adult Rodents: A Viral Vector-based Approach to Investigate Neuropeptide Function
Gabrielle E Callander, Sherie Ma, Despina E Ganella, Verena C Wimmer, Andrew L Gundlach, Walter G Thomas, Ross AD Bathgate
Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the n..