Neural networks and transmitters controlling behavioural state and cognition

Grant number: 1005988 | Funding period: 2011 - 2013

Completed

Abstract

Mental illness and dementia are significant social and economic burdens worldwide and knowledge of their underlying causes and more effective therapies are required. Our research aims to use pre-clinical models to characterize a little studied neuronal network implicated in control of brain theta rhythm activity, which could lead to improved treatment of neuropsychiatric diseases such as anxiety and depression, and degenerative cognitive decline.

Related publications (9)

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Chronic activation of the relaxin-3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance

Valeria Rytova, Despina E Ganella, David Hawkes, Ross AD Bathgate, Sherie Ma, Andrew L Gundlach

2019-10-01

Anxiety disorders are highly prevalent in modern society and better treatments are required. Key brain areas and signaling systems..

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Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders

Jigna Rajesh Kumar, Ramamoorthy Rajkumar, Tharindunee Jayakody, Subhi Marwari, Jia Mei Hong, Sherie Ma, Andrew L Gundlach, Mitchell KP Lai, Gavin S Dawe

2017-05-01

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Nucleus incertus promotes cortical desynchronization and behavioral arousal

Sherie Ma, Giancarlo Allocca, Emma KE Ong-Palsson, Caitlin E Singleton, David Hawkes, Stuart J McDougall, Spencer J Williams, Ross AD Bathgate, Andrew L Gundlach

2017-01-01

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Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala

Fabio N Santos, Celia W Pereira, Ana M Sanchez-Perez, Marcos Otero-Garcia, Sherie Ma, Andrew L Gundlach, Francisco E Olucha-Bordonau

2016-04-07

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Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuro psychiatric diseases?

Craig M Smith, Andrew W Walker, Ihaia T Hosken, Berenice E Chua, Cary Zhang, Mouna Haidar, Andrew L Gundlach

2014-03-21

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Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, CR Bye, AL Gundlach, RAD Bathgate

2013-07-01

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Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

Mohammed Akhter Hossain, Craig M Smith, Philip J Ryan, Elena Buechler, Ross AD Bathgate, Andrew L Gundlach, John D Wade

2013-06-01

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Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies

Anna Blasiak, Tomasz Blasiak, Marian H Lewandowski, Mohammed Akhter Hossain, John D Wade, Andrew L Gundlach

2013-04-01

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Silencing Relaxin-3 in Nucleus Incertus of Adult Rodents: A Viral Vector-based Approach to Investigate Neuropeptide Function

Gabrielle E Callander, Sherie Ma, Despina E Ganella, Verena C Wimmer, Andrew L Gundlach, Walter G Thomas, Ross AD Bathgate

2012-08-02