Neural networks and transmitters controlling behavioural state and cognition

Analysis of morphological and neurochemical changes in subthalamic nucleus neurons in response to a unilateral 6-OHDA lesion of the substantia nigra in adult rats

Katayoun Sedaghat, Andrew L Gundlach, David Finkelstein

2021-06-01

Background: Subthalamic nucleus (STN) neurons undergo changes in their pattern of activity and morphology during the clinical cour..

Chronic activation of the relaxin-3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance

Valeria Rytova, Despina E Ganella, David Hawkes, Ross AD Bathgate, Sherie Ma, Andrew L Gundlach

2019-10-01

Anxiety disorders are highly prevalent in modern society and better treatments are required. Key brain areas and signaling systems..

Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders

Jigna Rajesh Kumar, Ramamoorthy Rajkumar, Tharindunee Jayakody, Subhi Marwari, Jia Mei Hong, Sherie Ma, Andrew L Gundlach, Mitchell KP Lai, Gavin S Dawe

2017-05-01

Relaxin-3 has been proposed to modulate emotional-behavioural functions such as arousal and behavioural activation, appetite regul..

Nucleus incertus promotes cortical desynchronization and behavioral arousal

Sherie Ma, Giancarlo Allocca, Emma KE Ong-Palsson, Caitlin E Singleton, David Hawkes, Stuart J McDougall, Spencer J Williams, Ross AD Bathgate, Andrew L Gundlach

2017-01-01

Arousal and vigilance are essential for survival and relevant regulatory neural circuits lie within the brainstem, hypothalamus an..

Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala

Fabio N Santos, Celia W Pereira, Ana M Sanchez-Perez, Marcos Otero-Garcia, Sherie Ma, Andrew L Gundlach, Francisco E Olucha-Bordonau

2016-04-07

The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerfu..

Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3/RXFP3 Deficiency

Mouna Haidar, Monica Lam, Berenice E Chua, Craig M Smith, Andrew L Gundlach

2016-03-01

Methamphetamine (METH) is a highly addictive psychostimulant, and cessation of use is associated with reduced monoamine signalling..

ANXIOGENIC DRUG ADMINISTRATION AND ELEVATED PLUS-MAZE EXPOSURE IN RATS ACTIVATE POPULATIONS OF RELAXIN-3 NEURONS IN THE NUCLEUS INCERTUS AND SEROTONERGIC NEURONS IN THE DORSAL RAPHE NUCLEUS

AJ Lawther, ML Clissold, S Ma, S Kent, CA Lowry, AL Gundlach, MW Hale

2015-09-10

Anxiety is a complex and adaptive emotional state controlled by a distributed and interconnected network of brain regions, and dis..

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuro psychiatric diseases?

Craig M Smith, Andrew W Walker, Ihaia T Hosken, Berenice E Chua, Cary Zhang, Mouna Haidar, Andrew L Gundlach

2014-03-21

Animal and clinical studies of gene-environment interactions have helped elucidate the mechanisms involved in the pathophysiology ..

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, CR Bye, AL Gundlach, RAD Bathgate

2013-07-01

Relaxin-3 is a neuropeptide that is abundantly expressed by discrete brainstem neuron populations that broadly innervate forebrain..

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

Mohammed Akhter Hossain, Craig M Smith, Philip J Ryan, Elena Buechler, Ross AD Bathgate, Andrew L Gundlach, John D Wade

2013-06-01

The insulin-like peptide, relaxin-3 was first identified just a decade ago via a genomic database search and is now recognized to ..

Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies

Anna Blasiak, Tomasz Blasiak, Marian H Lewandowski, Mohammed Akhter Hossain, John D Wade, Andrew L Gundlach

2013-04-01

Behavioural state is controlled by a range of neural systems that are sensitive to internal and external stimuli. The relaxin-3 an..

Silencing Relaxin-3 in Nucleus Incertus of Adult Rodents: A Viral Vector-based Approach to Investigate Neuropeptide Function

Gabrielle E Callander, Sherie Ma, Despina E Ganella, Verena C Wimmer, Andrew L Gundlach, Walter G Thomas, Ross AD Bathgate

2012-08-02

Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the n..