Biologically individualised treatment for lung cancer

Grant number: 1003895 | Funding period: 2011 - 2016

Completed

Abstract

Positron Emission Tomography (PET)/Computed Tomography (CT) scanners pinpoint the location of cancer cells in people prior to and after treatment. This innovative study will use during treatment PET/CT scans to establish the response of lung tumours to radiation therapy (RT). We will use these scans to simulate the delivery of highly targeted, individualised RT and to predict patient prognosis, with the ultimate aim of increasing survival and minimising side effects in patients with lung cancer

Related publications (6)

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Robust, independent and relevant prognostic F-18-fluorodeoxyglucose positron emission tomography radiomics features in non-small cell lung cancer: Are there any?

Tom Konert, Sarah Everitt, Matthew D La Fontaine, Jeroen B van de Kamer, Michael P MacManus, Wouter V Vogel, Jason Callahan, Jan-Jakob Sonke

2020-02-25

In locally advanced lung cancer, established baseline clinical variables show limited prognostic accuracy and 18F-fluorodeoxygluco..

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PET-detected pneumonitis following curative-intent chemoradiation in non-small cell lung cancer (NSCLC): recognizing patterns and assessing the impact on the predictive ability of FDG-PET/CT response assessment

Amir Iravani, Guy-Anne Turgeon, Tim Akhurst, Jason W Callahan, Mathias Bressel, Sarah J Everitt, Shankar Siva, Michael S Hofman, Rodney J Hicks, David L Ball, Michael P Mac Manus

2019-08-01

PURPOSE: Inflammatory FDG uptake in the lung (PET-pneumonitis) following curative-intent radiotherapy (RT)/chemo-RT (CRT) in non-s..

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Early Skeletal Muscle Loss in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation and Relationship to Survival

Nicole Kiss, Julian Beraldo, Sarah Everitt

2019-07-01

PURPOSE: Sarcopenia is associated with reduced survival in cancer. Currently, data on sarcopenia at presentation and muscle loss t..

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Prospective Study of Serial Imaging Comparing Fluorodeoxyglucose Positron Emission Tomography (PET) and Fluorothymidine PET During Radical Chemoradiation for Non-Small Cell Lung Cancer: Reduction of Detectable Proliferation Associated With Worse Survival

Sarah Everitt, David Ball, Rodney J Hicks, Jason Callahan, Nikki Plumridge, Jenny Trinh, Alan Herschtal, Tomas Kron, Michael Mac Manus

2017-11-15

PURPOSE: To investigate the associations between interim tumor responses on 18F-fluorodeoxyglucose (18F-FDG) positron emission tom..

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Acute radiation oesophagitis associated with 2-deoxy-2-[18F]fluoro-d-glucose uptake on positron emission tomography/CT during chemo-radiation therapy in patients with non-small-cell lung cancer

Sarah Everitt, Jason Callahan, Eman Obeid, Rodney J Hicks, Michael Mac Manus, David Ball

2017-10-01

INTRODUCTION: Acute radiation oesophagitis (ARO) is frequently experienced by patients receiving concurrent chemo-radiation therap..

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Spleen Volume Variation in Patients with Locally Advanced Non-Small Cell Lung Cancer Receiving Platinum-Based Chemo-Radiotherapy

Shu Wen Wen, Sarah J Everitt, Justin Bedo, Marine Chabrot, David L Ball, Benjamin Solomon, Michael MacManus, Rodney J Hicks, Andreas Moeller, Antoine Leimgruber

2015-11-24

There is renewed interest in the immune regulatory role of the spleen in oncology. To date, very few studies have examined macrosc..

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