Reelin gene and environment interaction in schizophrenia
Grant number: 1004129 | Funding period: 2011 - 2013
Schizophrenia is caused by an interaction of genetic predisposition and environmental risk factors such as stress or drug abuse. Reelin is a protein involved in the normal development of the brain but its levels are markedly reduced in schizophrenia. We will use mice with low levels of reelin in their brain and assess the effect of environmental stress and drugs of abuse. These studies could elucidate gene-environment interaction in schizophrenia and lead to new treatment strategies.
Related publications (3)
Reelin Haploinsufficiency and Late-Adolescent Corticosterone Treatment Induce Long-Lasting and Female-Specific Molecular Changes in the Dorsal Hippocampus
Anna Schroeder, Maarten van den Buuse, Rachel A Hill
Reelin depletion and stress seem to affect similar pathways including GABAergic and glutamatergic signaling and both are implicate..
Gene-environment interaction of reelin and stress in cognitive behaviours in mice: Implications for schizophrenia
Anna Schroeder, Laetitia Buret, Rachel A Hill, Maarten van den Buuse
Cognitive deficits are a particularly debilitating symptom group in schizophrenia. We investigated the effect of a 'two hit' combi..
Corticosterone treatment during adolescence induces down-regulation of reelin and NMDA receptor subunit GLUN2C expression only in male mice: implications for schizophrenia
Laetitia Buret, Maarten van den Buuse
Stress exposure during adolescence/early adulthood has been shown to increase the risk for psychiatric disorders such as schizophr..