INTERROGATION OF TWO NOVEL GENETIC SUSCEPTIBILITY LOCI FOR MULTIPLE SCLEROSIS

Grant number: 633275 | Funding period: 2010 - 2012

Completed

Abstract

This proposal, from the Australia and New Zealand multiple sclerosis (MS) Genetics Consortium, aims to interrogate two new genes that it recently identified as predisposing for the development of MS. Both of the genes underlying these findings are also associated with risk of developing other autoimmune diseases such as type 1 diabetes, rheumatoid arthritis and Graves' disease.

Related publications (8)

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Class II HLA interactions modulate genetic risk for multiple sclerosis

Loukas Moutsianas, Luke Jostins, Ashley H Beecham, Alexander T Dilthey, Dionysia K Xifara, Maria Ban, Tejas S Shah, Nikolaos A Patsopoulos, Lars Alfredsson, Carl A Anderson, Katherine E Attfield, Sergio E Baranzini, Jeffrey Barrett, Thomas MC Binder, David Booth, Dorothea Buck, Elisabeth G Celius, Chris Cotsapas, Sandra D'Alfonso, Calliope A Dendrou

2015-10-01

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The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells

Fernando Shahijanian, Grant P Parnell, Fiona C McKay, Prudence N Gatt, Maryam Shojoei, Kate S O'Connor, Stephen D Schibeci, Fabienne Brilot, Christopher Liddle, Marcel Batten, Graeme J Stewart, David R Booth

2014-03-15

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Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes

Adrian Cortes, Judith Field, Evgeny A Glazov, Johanna Hadler, Jim Stankovich, Matthew A Brown

2013-06-01

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A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration

Ben J Gu, Paul N Baird, Kirstan A Vessey, Kristen K Skarratt, Erica L Fletcher, Stephen J Fuller, Andrea J Richardson, Robyn H Guymer, James S Wiley

2013-04-01

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Identity-by-Descent Mapping to Detect Rare Variants Conferring Susceptibility to Multiple Sclerosis

Rui Lin, Jac Charlesworth, Jim Stankovich, Victoria M Perreau, Matthew A Brown, Bruce V Taylor

2013-03-05

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A genome-wide association study in progressive multiple sclerosis

Filippo Martinelli-Boneschi, Federica Esposito, Paola Brambilla, Eva Lindstrom, Giovanni Lavorgna, Jim Stankovich, Mariaemma Rodegher, Ruggero Capra, Angelo Ghezzi, Gabriella Coniglio, Bruno Colombo, Melissa Sorosina, Vittorio Martinelli, David Booth, Annette Bang Oturai, Graeme Stewart, Hanne F Harbo, Trevor John Kilpatrick, Jan Hillert, Justin P Rubio

2012-10-01

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Interleukin-6 Gene Promoter-572 C Allele may Play a Role in Rate of Disease Progression in Multiple Sclerosis

Jun Yan, Jia Liu, Clement Yihao Lin, Peter A Csurhes, Michael P Pender, Pamela A McCombe, Judith M Greer

2012-10-01

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A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis

Judith Field, Sharon R Browning, Laura J Johnson, Patrick Danoy, Michael D Varney, Brian D Tait, Kaushal S Gandhi, Jac C Charlesworth, Robert N Heard, Graeme J Stewart, Trevor J Kilpatrick, Simon J Foote, Melanie Bahlo, Helmut Butzkueven, James Wiley, David R Booth, Bruce V Taylor, Matthew A Brown, Justin P Rubio, Jim Stankovich

2010-10-26