The long-term consequences of toluene exposure on the maturing brain.
Grant number: DP110100379 | Funding period: 2011 - 2013
Inhalant abuse is a significant problem especially among adolescent and indigenous communities. This project will provide insights into the long-term neurobiological consequences following inhalant exposure during adolescence when critical aspects of brain development are still occurring and how these may relate to altered behaviour in adulthood.
Related publications (10)
Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex
Alec LW Dick, Qiongyi Zhao, Rose Crossin, Danay Baker-Andresen, Xiang Li, Janette Edson, Simone Roeh, Victoria Marshall, Timothy W Bredy, Andrew J Lawrence, Jhodie R Duncan
Inhalants containing the volatile solvent toluene are misused to induce euphoria or intoxication. Inhalant abuse is most common du..
The persistence of growth impairments associated with adolescent inhalant abuse following sustained abstinence
Rose Crossin, Sheree Cairney, Andrew John Lawrence, Jhodie Rubina Duncan
Background: Abuse of inhalants containing the volatile solvent toluene is a significant public health issue, especially for adoles..
Adolescent inhalant abuse leads to other drug use and impaired growth; implications for diagnosis
Rose Crossin, Sheree Cairney, Andrew J Lawrence, Jhodie R Duncan
OBJECTIVE: Abuse of inhalants containing the volatile solvent toluene is a significant public health issue, especially for adolesc..
Toluene inhalation in adolescent rats reduces flexible behaviour in adulthood and alters glutamatergic and GABAergic signalling
Teri M Furlong, Jhodie R Duncan, Laura H Corbit, Caroline D Rae, Benjamin D Rowlands, Anthony D Maher, Fatima A Nasrallah, Carol J Milligan, Steven Petrou, Andrew J Lawrence, Bernard W Balleine
Toluene is a commonly abused inhalant that is easily accessible to adolescents. Despite the increasing incidence of use, our under..
Chronic intermittent toluene inhalation in adolescent rats results in metabolic dysfunction with altered glucose homeostasis
ALW Dick, A Simpson, A Qama, Z Andrews, AJ Lawrence, JR Duncan
BACKGROUND AND PURPOSE: Abuse of toluene-containing inhalants is an increasing public health problem, especially among adolescents..
NMDA receptor binding is reduced within mesocorticolimbic regions following chronic inhalation of toluene in adolescent rats
Alec Lindsay Ward Dick, Tine Pooters, Sarah Gibbs, Emma Giles, Ashleigh Qama, Andrew John Lawrence, Jhodie Rubina Duncan
The purposeful inhalation of volatile solvents, such as toluene, to induce self-intoxication is prevalent, particularly within ado..
Chronic intermittent toluene inhalation initiated during adolescence in rats does not alter voluntary consumption of ethanol in adulthood
Alec LW Dick, Andrew J Lawrence, Jhodie R Duncan
Voluntary inhalation of organic solvents, such as toluene, is particularly prevalent in adolescent populations and is considered t..
Specific impairments in instrumental learning following chronic intermittent toluene inhalation in adolescent rats
Alec LW Dick, Martin Axelsson, Andrew J Lawrence, Jhodie R Duncan
RATIONALE: Inhalant abuse is prevalent in adolescent populations, with chronic use resulting in neurobiological and cognitive abno..
Adolescent Toluene Inhalation in Rats Affects White Matter Maturation with the Potential for Recovery Following Abstinence
Jhodie Rubina Duncan, Alec Lindsay Ward Dick, Gary Egan, Scott Kolbe, Maria Gavrilescu, David Wright, Dan Ian Lubman, Andrew John Lawrence
Inhalant misuse is common during adolescence, with ongoing chronic misuse associated with neurobiological and cognitive abnormalit..