Atypical T cell receptor recognition of monomorphic CD1 antigen-presenting molecule
Grant number: DP110104124 | Funding period: 2011 - 2013
T lymphocytes are white blood cells that respond to foreign molecules (antigens). Until recently, most known antigens were proteins. This project will study how T lymphocytes recognise a different class of antigen (glycolipids) that are likely to play an equally important role in the immune system.
Related publications (1)
The molecular bases of delta/alpha beta T cell-mediated antigen recognition
Daniel G Pellicci, Adam P Uldrich, Jerome Le Nours, Fiona Ross, Eric Chabrol, Sidonia BG Eckle, Renate de Boer, Ricky T Lim, Kirsty McPherson, Gurdyal Besra, Amy R Howell, Lorenzo Moretta, James McCluskey, Mirjam HM Heemskerk, Stephanie Gras, Jamie Rossjohn, Dale I Godfrey
αβ and γδ T cells are disparate T cell lineages that can respond to distinct antigens (Ags) via the use of the αβ and γδ T cell Ag..