Resolving the Structures of Human Muscarinic M1 and M4 Receptors.
Grant number: DP110100086 | Funding period: 2011 - 2014
Muscarinic receptors are vital for most basic human brain functions. These receptors are changed in schizophrenia and Alzheimer's disease. This project will determine the structure and localisation of two of these receptors in order to i) understand their roles in brain disorders and ii) develop drugs to treat disorders involving them.
Related publications (2)
Low levels of muscarinic M1 receptor-positive neurons in cortical layers III and V in Brodmann areas 9 and 17 from individuals with schizophrenia
Elizabeth Scarr, Shaun Hopper, Valentina Vos, Myoung Suk Seo, Ian Paul Everall, Timothy Douglas Aumann, Gursharan Chana, Brian Dean
BACKGROUND: Results of neuroimaging and postmortem studies suggest that people with schizophrenia may have lower levels of muscari..
The distribution of muscarinic M1 receptors in the human hippocampus
Elizabeth Scarr, Myoung Suk Seo, Timothy Douglas Aumann, Gursharan Chana, Ian Paul Everall, Brian Dean
The muscarinic M1 receptor plays a significant role in cognition, probably by modulating information processing in key regions suc..