Biosynthesis, folding and modification of conotoxins
Grant number: DP110101331 | Funding period: 2011 - 2013
Disulfide-rich peptides represent a diverse family of bioactive molecules which have been developed as drugs for the treatment of severe pain. This project seeks to understand their biosynthesis and how their functional diversity is generated. Such information will assist the translation of more of these novel peptides into new drugs.
Related publications (6)
Hormone-like peptides in the venoms of marine cone snails
Samuel D Robinson, Qing Li, Pradip K Bandyopadhyay, Joanna Gajewiak, Mark Yandell, Anthony T Papenfuss, Anthony W Purcell, Raymond S Norton, Helena Safavi-Hemami
The venoms of cone snails (genus Conus) are remarkably complex, consisting of hundreds of typically short, disulfide-rich peptides..
A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed beta-Hairpin Fold
Samuel D Robinson, Sandeep Chhabra, Alessia Belgi, Balasubramanyam Chittoor, Helena Safavi-Hemami, Andrea J Robinson, Anthony T Papenfuss, Anthony W Purcell, Raymond S Norton
Certain peptide folds, owing to a combination of intrinsic stability and resilience to amino acid substitutions, are particularly ..
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom
Samuel D Robinson, Helena Safavi-Hemami, Shrinivasan Raghuraman, Julita S Imperial, Anthony T Papenfuss, Russell W Teichert, Anthony W Purcell, Baldomero M Olivera, Raymond S Norton
UNLABELLED: In this study, a proteogenomic annotation strategy was used to identify a novel bioactive peptide from the venom of th..
Combined Proteomic and Transcriptomic Interrogation of the Venom Gland of Conus geographus Uncovers Novel Components and Functional Compartmentalization*
Helena Safavi-Hemami, Hao Hu, Dhana G Gorasia, Pradip K Bandyopadhyay, Paul D Veith, Neil D Young, Eric C Reynolds, Mark Yandell, Baldomero M Olivera, Anthony W Purcell
Cone snails are highly successful marine predators that use complex venoms to capture prey. At any given time, hundreds of toxins ..
Modulation of Conotoxin Structure and Function Is Achieved through a Multienzyme Complex in the Venom Glands of Cone Snails
Helena Safavi-Hemami, Dhana G Gorasia, Andrew M Steiner, Nicholas A Williamson, John A Karas, Joanna Gajewiak, Baldomero M Olivera, Grzegorz Bulaj, Anthony W Purcell
The oxidative folding of large polypeptides has been investigated in detail; however, comparatively little is known about the enzy..
Embryonic Toxin Expression in the Cone Snail Conus victoriae PRIMED TO KILL OR DIVERGENT FUNCTION?
Helena Safavi-Hemami, William A Siero, Zhihe Kuang, Nicholas A Williamson, John A Karas, Louise R Page, David MacMillan, Brid Callaghan, Shiva Nag Kompella, David J Adams, Raymond S Norton, Anthony W Purcell
Predatory marine cone snails (genus Conus) utilize complex venoms mainly composed of small peptide toxins that target voltage- and..