THE ROLE OF NEURON-GLIA INTERACTIONS IN REGULATING CELL SURVIVAL AND MYELINATION IN MULTIPLE SCLEROSIS

Grant number: 1013504 | Funding period: 2011 - 2016

Completed

Abstract

Multiple sclerosis is a particularly devastating disease that affects people early in their lives. This chronic disabling condition is characterized by inflammation and loss or damage to the myelin sheath that surrounds axons. There is preliminary evidence suggesting that certain cell signals may prevent the cells that produce myelin from death in multiple sclerosis. This study will seek to determine how and which signals prevent cell death and whether this may be a potential therapeutic intervention.