Neural Control of Behavioural State in Health and Disease

Chronic activation of the relaxin-3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance

V Rytova, DE Ganella, D Hawkes, RAD Bathgate, S Ma, AL Gundlach

2019-10-01

Anxiety disorders are highly prevalent in modern society and better treatments are required. Key brain areas and signaling systems..

Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice

AW Walker, CM Smith, AL Gundlach, AJ Lawrence

2015-11-01

The pervasive use of refined sugars in highly accessible, palatable foods and persistent exposure to reinforcing food-associated c..

Involvement of central relaxin-3 signalling in sodium (salt) appetite

CM Smith, LL Walker, BE Chua, MJ Mckinley, AL Gundlach, DA Denton, AJ Lawrence

2015-09-01

New Findings: What is the central question of this study? Sodium appetite is controlled by conserved neuronal transmitter-receptor..

Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice

AW Walker, CM Smith, BE Chua, EV Krstew, C Zhang, AL Gundlach, AJ Lawrence

2015-04-07

Stressful life events are causally linked with alcohol use disorders (AUDs), providing support for a hypothesis that alcohol consu..

Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat

S Ma, A Blasiak, FE Olucha-Bordonau, AJM Verberne, AL Gundlach

2013-08-01

Abstract The nucleus incertus (NI) of the rat hindbrain is a putative node in the ascending control of the septohippocampal system..

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, CR Bye, AL Gundlach, RAD Bathgate

2013-07-01

Relaxin-3 is a neuropeptide that is abundantly expressed by discrete brainstem neuron populations that broadly innervate forebrain..

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

MA Hossain, CM Smith, PJ Ryan, E Büchler, RAD Bathgate, AL Gundlach, JD Wade

2013-06-01

The insulin-like peptide, relaxin-3 was first identified just a decade ago via a genomic database search and is now recognized to ..

Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies

A Blasiak, T Blasiak, MH Lewandowski, MA Hossain, JD Wade, AL Gundlach

2013-04-01

Behavioural state is controlled by a range of neural systems that are sensitive to internal and external stimuli. The relaxin-3 an..

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, AL Gundlach, RAD Bathgate, CR Bye

2012-11-08

Relaxin-3 is a neuropeptide that is abundantly expressed by discrete brainstem neuron populations that broadly innervate forebrain..

Silencing relaxin-3 in nucleus incertus of adult rodents: A viral vector-based approach to investigate neuropeptide function

GE Callander, S Ma, DE Ganella, VC Wimmer, AL Gundlach, WG Thomas, RAD Bathgate

2012-08-02

Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the n..