The cause of psychiatric disease

Altered levels of dopamine transporter in the frontal pole and the striatum in mood disorders: A postmortem study.

Hirotaka Sekiguchi, Geoff Pavey, Brian Dean

2023-01-01

Dopamine dysregulation is known to play a major role in the pathophysiology of major depressive disorders (MDD) and bipolar disord..

Common changes in rat cortical gene expression after chronic treatment with chlorpromazine and haloperidol may be related to their antipsychotic efficacy

Brian Dean, Elizabeth Scarr

2023-01-01

An investigation into nicotinic receptor involvement in mood disorders uncovers novel depression candidate genes

Andrew Gibbons, Kate McPherson, Andrea Gogos, Brian Dean

2021-04-22

BACKGROUND: We have previously reported reduced expression of the cholinergic autoreceptor CHRM2 in Brodmann's Area (BA) 24 of the..

The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder

Srisaiyini Kidnapillai, Chiara C Bortolasci, Madhara Udawela, Bruna Panizzutti, Briana Spolding, Timothy Connor, Andrew Sanigorski, Olivia M Dean, Tamsyn Crowley, Stephane Jamain, Laura Gray, Elizabeth Scarr, Marion Leboyer, Brian Dean, Michael Berk, Ken Walder

2020-11-25

To create a gene expression signature (GES) to represent the biological effects of a combination of known drugs for bipolar disord..

SMAD4 protein is decreased in the dorsolateral prefrontal and anterior cingulate cortices in schizophrenia

Andrew S Gibbons, Daniel Hoyer, Brian Dean

2020-03-02

OBJECTIVES: Signal transduction through the mothers against decapentaplegic (SMAD) is a family of signal transduction factors that..

Altered levels of dopamine transporter in the frontal pole and dorsal striatum in schizophrenia

Hirotaka Sekiguchi, Geoff Pavey, Brian Dean

2019-12-02

The dopamine hypothesis proposes that there is a hypodopaminergic state in the prefrontal cortex and a hyperdopaminergic state in ..

Changed cortical risk gene expression in major depression and shared changes in cortical gene expression between major depression and bipolar disorders

Elizabeth Scarr, Madhara Udawela, Brian Dean

2019-12-01

BACKGROUND: Mood disorders likely occur in someone with a genetic predisposition who encounters a deleterious environmental factor..

Cortical biometals: Changed levels in suicide and with mood disorders

Brian Dean, Linh Q Lam, Elizabeth Scarr, James A Duce

2019-01-15

BACKGROUND: Changes in levels of metals have been suggested to contribute to the pathophysiologies of several neurodegenerative di..

Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia

Elizabeth Scarr, Madhara Udawela, Brian Dean

2018-02-20

Schizophrenia (Sz) probably occurs after genetically susceptible individuals encounter a deleterious environmental factor that tri..

Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor

E Scarr, M Udawela, EA Thomas, B Dean

2018-02-01

We tested the hypothesis that, compared with subjects with no history of psychiatric illness (controls), changes in gene expressio..

Higher levels of different muscarinic receptors in the cortex and hippocampus from subjects with Alzheimer's disease

Elizabeth Scarr, Catriona McLean, Brian Dean

2017-03-01

It has been suggest that drugs specifically targeting muscarinic receptors will be useful in treating Alzheimer's disease. We deci..

Muscarinic receptor binding changes in postmortem Parkinson's disease

Caitlin McOmish, Geoff Pavey, Catriona McLean, Malcolm Horne, Brian Dean, Elizabeth Scarr

2017-02-01

Parkinson's disease (PD) is a devastating disorder, affecting approximately 2% of people aged 60 and above. It is marked by progre..

Fatty acid composition of the postmortem corpus callosum of patients with schizophrenia, bipolar disorder, or major depressive disorder

K Hamazaki, M Maekawa, T Toyota, B Dean, T Hamazaki, T Yoshikawa

2017-01-01

BACKGROUND: Studies investigating the relationship between n-3 polyunsaturated fatty acid (PUFA) levels and psychiatric disorders ..

Evidence for impaired glucose metabolism in the striatum, obtained postmortem, from some subjects with schizophrenia

B Dean, N Thomas, E Scarr, M Udawela

2016-11-15

Studies using central nervous system tissue obtained postmortem suggest pathways involved in energy and metabolism contribute to t..

Analysis of induced pluripotent stem cells carrying 22q11.2 deletion

M Toyoshima, W Akamatsu, Y Okada, T Ohnishi, S Balan, Y Hisano, Y Iwayama, T Toyota, T Matsumoto, N Itasaka, S Sugiyama, M Tanaka, M Yano, B Dean, H Okano, T Yoshikawa

2016-11-01

Given the complexity and heterogeneity of the genomic architecture underlying schizophrenia, molecular analyses of these patients ..

The distribution of muscarinic M1 receptors in the human hippocampus

Elizabeth Scarr, Myoung Suk Seo, Timothy Douglas Aumann, Gursharan Chana, Ian Paul Everall, Brian Dean

2016-11-01

The muscarinic M1 receptor plays a significant role in cognition, probably by modulating information processing in key regions suc..

Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank

Brian Dean, David Copolov, Elizabeth Scarr

2016-11-01

The Melbourne Psychiatric Brain Bank came into existence 25years ago. This review focusses on lines of research that have used tis..

COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex

Brian Dean, Elizabeth Scarr

2016-09-01

Catechol-O-methyltransferase (COMT) genotype has been associated with varying levels of cognitive functioning and an altered risk ..

Validating reference genes using minimally transformed qpcr data: findings in human cortex and outcomes in schizophrenia

Brian Dean, Madhara Udawela, Elizabeth Scarr

2016-05-20

BACKGROUND: It is common practice, when using quantitative real time polymerase chain reaction (qPCR), to normalise levels of mRNA..

Changes in BQCA Allosteric Modulation of [H-3]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations

Brian Dean, Shaun Hopper, P Jeffrey Conn, Elizabeth Scarr

2016-05-01

Stimulation of the cortical muscarinic M1 receptor (CHRM1) is proposed as a treatment for schizophrenia, a hypothesis testable usi..

Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants

Andrew Stuart Gibbons, Won Je Jeon, Elizabeth Scarr, Brian Dean

2016-04-01

BACKGROUND: Increasingly, data are implicating muscarinic receptors in the aetiology and treatment of mood disorders. This led us ..

Fatty acid composition and fatty acid binding protein expression in the postmortem frontal cortex of patients with schizophrenia: A case-control study

Kei Hamazaki, Motoko Maekawa, Tomoko Toyota, Yoshimi Iwayama, Brian Dean, Tomohito Hamazaki, Takeo Yoshikawa

2016-03-01

BACKGROUND: Abnormal levels of n-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), have been found i..

Lower [3H]LY341495 binding to mGlu2/3 receptors in the anterior cingulate of subjects with major depressive disorder but not bipolar disorder or schizophrenia

Caitlin E McOmish, Geoff Pavey, Andrew Gibbons, Shaun Hopper, Madhara Udawela, Elizabeth Scarr, Brian Dean

2016-01-15

INTRODUCTION: The glutamatergic system has recently been implicated in the pathogenesis and treatment of major depressive disorder..

Changes in cholinergic and glutamatergic markers in the striatum from a sub-set of subjects with schizophrenia

Brian Dean, Natalie Thomas, Chi-Yu Lai, Wei J Chen, Elizabeth Scarr

2015-12-01

BACKGROUND/OBJECTIVES: Having separated a sub-group of people with schizophrenia based on a marked loss of cortical [(3)H]pirenzep..

The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia

Vanessa L Cropley, Elizabeth Scarr, Alex Fornito, Paul Klauser, Chad A Bousman, Rodney Scott, Murray J Cairns, Paul A Tooney, Christos Pantelis, Brian Dean

2015-11-30

Previous research has demonstrated that individuals with schizophrenia who are homozygous at the c.267C>A single nucleotide polymo..

Biomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank

Elizabeth Scarr, Mark J Millan, Sabine Bahn, Alessandro Bertolino, Christoph W Turck, Shitij Kapur, Hans-Juergen Moeller, Brian Dean

2015-09-01

BACKGROUND: A think tank sponsored by the Collegium Internationale Neuropsychopharmacologium (CINP) debated the status and prospec..

SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia

M Udawela, TT Money, J Neo, MS Seo, E Scarr, B Dean, IP Everall

2015-08-04

Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from..

Fatty acid composition of the postmortem prefrontal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder

Kei Hamazaki, Motoko Maekawa, Tomoko Toyota, Brian Dean, Tomohito Hamazaki, Takeo Yoshikawa

2015-06-30

Postmortem brain studies have shown abnormal levels of n-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid, i..

Autophagy has a key role in the pathophysiology of schizophrenia

A Merenlender-Wagner, A Malishkevich, Z Shemer, M Udawela, A Gibbons, E Scarr, B Dean, J Levine, G Agam, I Gozes

2015-02-01

Autophagy is a process preserving the balance between synthesis, degradation and recycling of cellular components and is therefore..

The Role of Muscarinic Receptors in the Pathophysiology of Mood Disorders: A Potential Novel Treatment?

Won Je Jeon, Brian Dean, Elizabeth Scarr, Andrew Gibbons

2015-01-01

The central cholinergic system has been implicated in the pathophysiology of mood disorders. An imbalance in central cholinergic n..

Potential Molecular and Cellular Mechanism of Psychotropic Drugs

Myoung Suk Seo, Elizabeth Scarr, Chi-Yu Lai, Brian Dean

2014-08-01

Psychiatric disorders are among the most debilitating of all medical illnesses. Whilst there are drugs that can be used to treat t..

Lower cortical serotonin 2A receptors in major depressive disorder, suicide and in rats after administration of imipramine

Brian Dean, Nahed Tawadros, Myoung Suk Seo, Won Je Jeon, Ian Everall, Elizabeth Scarr, Andrew Gibbons

2014-06-01

We have attempted to replicate studies showing higher levels of serotonin 2A receptors (HTR2A) in the cortex of people with mood d..

Cholinergic muscarinic M-4 receptor gene polymorphisms: A potential risk factor and pharmacogenomic marker for schizophrenia

Elizabeth Scarr, Jung Yoon Um, Tiffany Frances Cowie, Brian Dean

2013-05-01

Although schizophrenia is a widespread disorder of unknown aetiology, we have previously shown that muscarinic M4 receptor (CHRM4)..

Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

E Scarr, JM Craig, MJ Cairns, MS Seo, JC Galati, NJ Beveridge, A Gibbons, S Juzva, B Weinrich, M Parkinson-Bates, AP Carroll, R Saffery, B Dean

2013-02-01

Many studies have shown decreased cortical muscarinic M1 receptors (CHRM1) in schizophrenia (Sz), with one study showing Sz can be..

Mu opioid receptor availability in people with psychiatric disorders who died by suicide: a case control study

Elizabeth Scarr, Tammie Terese Money, Geoffrey Pavey, Jaclyn Neo, Brian Dean

2012-08-28

BACKGROUND: Mu opioid receptors have previously been shown to be altered in people with affective disorders who died as a result o..

Muscarinic M1 receptor sequence: Preliminary studies on its effects on cognition and expression

Elizabeth Scarr, Suresh Sundram, Azita Deljo, Tiffany Francis Cowie, Andrew Stuart Gibbons, Susan Juzva, Andrew Mackinnon, Stephen J Wood, Renee Testa, Christos Pantelis, Brian Dean

2012-06-01

It has been reported that people with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism of the choli..

Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia

Bin Tang, Cristina Capitao, Brian Dean, Elizabeth A Thomas

2012-04-30

We have previously identified differential effects of age on global brain gene expression profiles in subjects with schizophrenia ..

Altered neuronal markers following treatment with mood stabilizer and antipsychotic drugs indicate an increased likelihood of neurotransmitter release.

Elizabeth Scarr, Brian Dean

2012-04-01

OBJECTIVE: Given the ability of mood stabilizers and antipsychotics to promote cell proliferation, we wanted to determine the effe..

AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder

Andrew Stuart Gibbons, Lucy Brooks, Elizabeth Scarr, Brian Dean

2012-02-01

BACKGROUND: Glutamate is thought to be involved in the pathophysiology of major depressive disorder and bipolar disorder; however,..

Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders

B Tang, B Dean, EA Thomas

2011-12-01

Increasing evidence suggests that epigenetic factors have critical roles in gene regulation in neuropsychiatric disorders and in a..

Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies

Brian Dean

2011-08-01

Many lines of evidence now support the hypothesis that inflammation-related pathways are involved in the pathophysiology of psychi..

Dissecting the Syndrome of Schizophrenia: Progress toward Clinically Useful Biomarkers

Brian Dean

2011-01-01

The search for clinically useful biomarkers has been one of the holy grails of schizophrenia research. This paper will outline the..