Development of nerve cells in the bowel
Grant number: 1002506 | Funding period: 2011 - 2016
Gut motility requires enteric neurons, which are located in the gut wall. During development, enteric neurons arise from precursors in the brain that migrate into the intestine. Failure of enteric neuron precursors to migrate and differentiate normally results in pediatric motility disorders. The aim of this research is to identify the mechanisms controlling the development of enteric neurons so that therapies can be developed for pediatric motility disorders.
Related publications (12)
Spontaneous calcium waves in the developing enteric nervous system
Marlene M Hao, Annette J Bergner, Caroline S Hirst, Lincon A Stamp, Franca Casagranda, Joel C Bornstein, Werend Boesmans, Pieter Vanden Berghe, Heather M Young
The enteric nervous system (ENS) is an extensive network of neurons in the gut wall that arises from neural crest-derived cells. L..
Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells
Lincon A Stamp, Rachel M Gwynne, Jaime PP Foong, Alan E Lomax, Marlene M Hao, David I Kaplan, Christopher A Reid, Steven Petrou, Andrew M Allen, Joel C Bornstein, Heather M Young
BACKGROUND & AIMS: Cell therapy offers the potential to treat gastrointestinal motility disorders caused by diseased or absent ent..
Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System
Sonja J McKeown, Mitra Mohsenipour, Annette J Bergner, Heather M Young, Lincon A Stamp
Cell therapy is a promising approach to generate an enteric nervous system (ENS) and treat enteric neuropathies. However, for tran..
A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy
Ian A Parish, Lincon A Stamp, Ayla May D Lorenzo, Suzanne M Fowler, Yovina Sontani, Lisa A Miosge, Debbie R Howard, Christopher C Goodnow, Heather M Young, John B Furness
Chronic intestinal pseudo-obstruction (CIPO) is a rare but life-threatening disease characterized by severe intestinal dysmotility..
Ion Channel Expression in the Developing Enteric Nervous System
Caroline S Hirst, Jaime PP Foong, Lincon A Stamp, Emily Fegan, Stephan Dent, Edward C Cooper, Alan E Lomax, Colin R Anderson, Joel C Bornstein, Heather M Young, Sonja J McKeown
The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expre..
Different Neural Crest Populations Exhibit Diverse Proliferative Behaviors
David G Gonsalvez, Mathew Li-Yuen-Fong, Kylie N Cane, Lincon A Stamp, Heather M Young, Colin R Anderson
The rate of proliferation of cells depends on the proportion of cycling cells and the frequency of cell division. Here, we describ..
Colonizing while migrating: how do individual enteric neural crest cells behave?
Heather M Young, Annette J Bergner, Matthew J Simpson, Sonja J McKeown, Marlene M Hao, Colin R Anderson, Hideki Enomoto
BACKGROUND: Directed cell migration is essential for normal development. In most of the migratory cell populations that have been ..