TREATING CANCER BY TARGETING GENE MUTATIONS
Grant number: 1002654 | Funding period: 2011 - 2015
Major advances in cancer treatment has been made by identifying gene mutations in cancers to which the cancer is “addicted”, such that turning off the effects of the mutations leads to death of the cancer cells. Grant McArthur has been successful in applying this principle to rare types of sarcoma bringing his work to routine clinical practice globally. In this application he will investigate targeting the BRAF, KIT and MYC genes focusing on melanoma, a major cancer problem in Australia.
Related publications (4)
Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies
Andrew J Colebatch, Leon Di Stefano, Stephen Q Wong, Ross D Hannan, Paul M Waring, Alexander Dobrovic, Grant A McArthur, Anthony T Papenfuss
Most cancer DNA sequencing studies have prioritized recurrent non-synonymous coding mutations in order to identify novel cancer-re..
Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome
Lih Yin Tan, Chris Mintoff, M Zahied Johan, Brenton W Ebert, Clare Fedele, You Fang Zhang, Pacman Szeto, Karen E Sheppard, Grant A McArthur, Erwin Foster-Smith, Andrew Ruszkiewicz, Michael P Brown, Claudine S Bonder, Mark Shackleton, Lisa M Ebert
Tumors can develop a blood supply not only by promoting angiogenesis but also by forming vessel-like structures directly from tumo..
Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma
SQ Wong, A Behren, VJ Mar, K Woods, J Li, C Martin, KE Sheppard, R Wolfe, J Kelly, J Cebon, A Dobrovic, GA McArthur
Melanoma is often caused by mutations due to exposure to ultraviolet radiation. This study reports a recurrent somatic C > T chang..
Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma
Victoria J Mar, Stephen Q Wong, Aleksandra Logan, Nguyen Trung, Jonathan Cebon, John W Kelly, Rory Wolfe, Alexander Dobrovic, Catriona McLean, Grant A McArthur
Activating mutations in the GTPase RAC1 are a recurrent event in cutaneous melanoma. We investigated the clinical and pathological..