Bowel Cancer

Grant number: 1002117 | Funding period: 2011 - 2016

Completed

Abstract

Rob Ramsay has had a long standing research commitment to understanding bowel and breast cancer using mouse models with defined genetic defects. These sophisticated models replicate various stages of cancer development and some have profound effects on normal tissue biology. He also uses molecular tools to investigate how genes are controlled. These approaches are providing direct input into the development of therapeutic agents for cancer treatment.

Related publications (10)

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Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery

S Carpinteri, S Sampurno, J Malaterre, R Millen, M Dean, J Kong, T Chittleborough, A Heriot, AC Lynch, RG Ramsay

2018-04-01

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Intestinal-specific activatable Myb initiates colon tumorigenesis in mice

J Malaterre, L Pereira, T Putoczki, R Millen, S Paquet-Fifield, M Germann, J Liu, D Cheasley, S Sampurno, SA Stacker, MG Achen, RL Ward, P Waring, T Mantamadiotis, M Ernst, RG Ramsay

2016-05-12

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CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression

Partha Mitra, Ren-Ming Yang, James Sutton, Robert G Ramsay, Thomas J Gonda

2016-02-23

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Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer

Rosemary Millen, Jordane Malaterre, Ryan S Cross, Sandra Carpinteri, Jayesh Desai, Ben Tran, Phillip Darcy, Peter Gibbs, Oliver Sieber, Nikolajs Zeps, Paul Waring, Stephen Fox, Lloyd Pereira, Robert G Ramsay

2016-01-01

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Myb via TGF beta is required for collagen type 1 production and skin integrity

Shienny Sampurno, Ryan Cross, Helen Pearson, Pritinder Kaur, Jordane Malaterre, Robert G Ramsay

2015-04-01

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Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C Eder, Robyn L Ward, Nicholas J Hawkins, Richard W Tothill, Long Chen, Neil J Mortensen, Stephen B Fox, Michael J McKay, Robert G Ramsay

2014-12-11

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Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis

Markus Germann, Huiling Xu, Jordane Malaterre, Shienny Sampurno, Mathilde Huyghe, Dane Cheasley, Silvia Fre, Robert G Ramsay

2014-11-01

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Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface-Associated GRP78

Yu Rebecca Miao, Bedrich L Eckhardt, Yuan Cao, Renata Pasqualini, Pedram Argani, Wadih Arap, Robert G Ramsay, Robin L Anderson

2013-04-15

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The CSF-1 receptor fashions the intestinal stem cell niche

Dilara Akcora, Duy Huynh, Sally Lightowler, Markus Germann, Sylvie Robine, Jan R de May, Jeffrey W Pollard, E Richard Stanley, Jordane Malaterre, Robert G Ramsay

2013-03-01

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Myb Controls Intestinal Stem Cell Genes and Self-Renewal

Dane Cheasley, Lloyd Pereira, Sally Lightowler, Elizabeth Vincan, Jordane Malaterre, Robert G Ramsay

2011-12-01

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