Grant number: 1002117 | Funding period: 2011 - 2016
Rob Ramsay has had a long standing research commitment to understanding bowel and breast cancer using mouse models with defined genetic defects. These sophisticated models replicate various stages of cancer development and some have profound effects on normal tissue biology. He also uses molecular tools to investigate how genes are controlled. These approaches are providing direct input into the development of therapeutic agents for cancer treatment.
Related publications (10)
Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery
S Carpinteri, S Sampurno, J Malaterre, R Millen, M Dean, J Kong, T Chittleborough, A Heriot, AC Lynch, RG Ramsay
BACKGROUND: The aim of this study was to monitor the effect of humidified-warm carbon dioxide (HWCO2 ) delivered into the open abd..
Intestinal-specific activatable Myb initiates colon tumorigenesis in mice
J Malaterre, L Pereira, T Putoczki, R Millen, S Paquet-Fifield, M Germann, J Liu, D Cheasley, S Sampurno, SA Stacker, MG Achen, RL Ward, P Waring, T Mantamadiotis, M Ernst, RG Ramsay
Transcription factor Myb is overexpressed in most colorectal cancers (CRC). Patients with CRC expressing the highest Myb are more ..
CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression
Partha Mitra, Ren-Ming Yang, James Sutton, Robert G Ramsay, Thomas J Gonda
Our previous studies showed that MYB is required for proliferation of, and confers protection against apoptosis on, estrogen recep..
Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer
Rosemary Millen, Jordane Malaterre, Ryan S Cross, Sandra Carpinteri, Jayesh Desai, Ben Tran, Phillip Darcy, Peter Gibbs, Oliver Sieber, Nikolajs Zeps, Paul Waring, Stephen Fox, Lloyd Pereira, Robert G Ramsay
The presence of tumor immune infiltrating cells (TILs), particularly CD8(+) T-cells, is a robust predictor of outcome in patients ..
Myb via TGF beta is required for collagen type 1 production and skin integrity
Shienny Sampurno, Ryan Cross, Helen Pearson, Pritinder Kaur, Jordane Malaterre, Robert G Ramsay
Skin integrity requires an ongoing replacement and repair orchestrated by several cell types. We previously investigated the archi..
Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors
Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C Eder, Robyn L Ward, Nicholas J Hawkins, Richard W Tothill, Long Chen, Neil J Mortensen, Stephen B Fox, Michael J McKay, Robert G Ramsay
Loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene triggers a series of molecular events leading to intesti..
Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis
Markus Germann, Huiling Xu, Jordane Malaterre, Shienny Sampurno, Mathilde Huyghe, Dane Cheasley, Silvia Fre, Robert G Ramsay
Deletion studies confirm Wnt, Notch and Myb transcriptional pathway engagement in intestinal tumorigenesis. Nevertheless, their co..
Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface-Associated GRP78
Yu Rebecca Miao, Bedrich L Eckhardt, Yuan Cao, Renata Pasqualini, Pedram Argani, Wadih Arap, Robert G Ramsay, Robin L Anderson
PURPOSE: The major cause of morbidity in breast cancer is development of metastatic disease, for which few effective therapies exi..
The CSF-1 receptor fashions the intestinal stem cell niche
Dilara Akcora, Duy Huynh, Sally Lightowler, Markus Germann, Sylvie Robine, Jan R de May, Jeffrey W Pollard, E Richard Stanley, Jordane Malaterre, Robert G Ramsay
Gastrointestinal (GI) homeostasis requires the action of multiple pathways. There is some controversy regarding whether small inte..
Myb Controls Intestinal Stem Cell Genes and Self-Renewal
Dane Cheasley, Lloyd Pereira, Sally Lightowler, Elizabeth Vincan, Jordane Malaterre, Robert G Ramsay
Rapid advances have been made in the understanding of how the highly proliferative gastrointestinal tract epithelium is regulated ..