EFFECT OF TESTOSTERONE ON MUSCLE, BONE AND FAT
Grant number: 1017233 | Funding period: 2011 - 2015
Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases well being and contributes to muscle weakness, bone fragility and weight gain. Cutting edge technology will be used to help explain how AD may relate to these negative effects, particularly on muscle function. Given the importance of aging, frailty, osteoporosis and obesity, understanding the role of hormones in these conditions may have major implications for prevention and treatment.
Related publications (16)
Zoledronic acid does not affect insulin resistance in men receiving androgen deprivation therapy: a prespecified secondary analysis of a randomised controlled trial.
Ada S Cheung, Rudolf Hoermann, Jasmine Zhu, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
Background: Animal studies suggest that undercarboxylated osteocalcin may improve insulin sensitivity via its effect on testicular..
Differing Effects of Zoledronic Acid on Bone Microarchitecture and Bone Mineral Density in Men Receiving Androgen Deprivation Therapy: A Randomized Controlled Trial
Ada S Cheung, Rudolf Hoermann, Ali Ghasem-Zadeh, Alistair J Tinson, Vivian Ly, Stefan Milevski, Daryl Lim Joon, Jeffrey D Zajac, Ego Seeman, Mathis Grossmann
Androgen deprivation therapy (ADT) given to men with prostate cancer causes rapid and severe sex steroid deficiency, leading to in..
Biomechanical leg muscle function during stair ambulation in men receiving androgen deprivation therapy.
Ada S Cheung, Hans A Gray, Anthony G Schache, Rudolf Hoermann, Jarrod Bicknell, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann
BACKGROUND: The role of testosterone in maintaining functional performance in older men remains uncertain. METHODS: We conducted a..
Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer
Ada S Cheung, Casey de Rooy, Itamar Levinger, Kesha Rana, Michele V Clarke, Jackie M How, Andrew Garnham, Catriona McLean, Jeffrey D Zajac, Rachel A Davey, Mathis Grossmann
Androgen deprivation therapy (ADT) decreases muscle mass and function but no human studies have investigated the underlying geneti..
Hypothalamic-Pituitary-Thyroid Axis Set Point Alterations Are Associated With Body Composition in Androgen-Deprived Men
Rudolf Hoermann, Ada S Cheung, Michele Milne, Mathis Grossmann
Objective: Androgen deprivation therapy (ADT) given to men with prostate cancer is associated with metabolically adverse changes i..
Quality of life decrements in men with prostate cancer undergoing androgen deprivation therapy
Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospecti..
Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case-control study
Ada S Cheung, Hans Gray, Anthony G Schache, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann
BACKGROUND: Although muscle mass declines with testosterone deficiency in men, previous studies of muscle function have not demons..
Relationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer
Ada S Cheung, Rudolf Hoermann, Philippe Dupuis, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with insulin resistance and frailty, controlled prospectiv..
Correlation of visceral adipose tissue measured by Lunar Prodigy dual X-ray absorptiometry with MRI and CT in older men
AS Cheung, C de Rooy, R Hoermann, EJ Gianatti, EJ Hamilton, G Roff, JD Zajac, M Grossmann
Quantification of abdominal visceral adipose tissue (VAT) is important to understand obesity-related comorbidities. We hypothesize..
Testosterone levels increase in association with recovery from acute fracture in men
AS Cheung, S Baqar, R Sia, R Hoermann, S Iuliano-Burns, TDT Vu, C Chiang, EJ Hamilton, E Gianatti, E Seeman, JD Zajac, M Grossmann
UNLABELLED: In this longitudinal case-control study, acute fracture was associated with low serum testosterone, which was transien..
Cardiovascular risk and bone loss in men undergoing androgen deprivation therapy for non-metastatic prostate cancer: implementation of standardized management guidelines
AS Cheung, D Pattison, I Bretherton, R Hoermann, D Lim Joon, E Ho, T Jenkins, EJ Hamilton, K Bate, I Chan, JD Zajac, M Grossmann
Our objective was to evaluate the effectiveness of implementing standardized guidelines to mitigate metabolic and bone side effect..