EFFECT OF TESTOSTERONE ON MUSCLE, BONE AND FAT

Grant number: 1017233 | Funding period: 2011 - 2015

Completed

Abstract

Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases well being and contributes to muscle weakness, bone fragility and weight gain. Cutting edge technology will be used to help explain how AD may relate to these negative effects, particularly on muscle function. Given the importance of aging, frailty, osteoporosis and obesity, understanding the role of hormones in these conditions may have major implications for prevention and treatment.

Related publications (18)

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Zoledronic acid does not affect insulin resistance in men receiving androgen deprivation therapy: a prespecified secondary analysis of a randomised controlled trial

Ada S Cheung, Rudolf Hoermann, Jasmine Zhu, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

2021-05-01

BACKGROUND: Animal studies suggest that undercarboxylated osteocalcin may improve insulin sensitivity via its effect on testicular..

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Biomechanical Leg Muscle Function During Stair Ambulation in Men Receiving Androgen Deprivation Therapy

Ada S Cheung, Hans A Gray, Anthony G Schache, Rudolf Hoermann, Jarrod Bicknell, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann

2020-09-01

BACKGROUND: The role of testosterone in maintaining functional performance in older men remains uncertain. METHODS: We conducted a..

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Differing Effects of Zoledronic Acid on Bone Microarchitecture and Bone Mineral Density in Men Receiving Androgen Deprivation Therapy: A Randomized Controlled Trial

Ada S Cheung, Rudolf Hoermann, Ali Ghasem-Zadeh, Alistair J Tinson, Vivian Ly, Stefan Milevski, Daryl Lim Joon, Jeffrey D Zajac, Ego Seeman, Mathis Grossmann

2020-07-06

Androgen deprivation therapy (ADT) given to men with prostate cancer causes rapid and severe sex steroid deficiency, leading to in..

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Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy

Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd JG Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann

2019-06-01

CONTEXT: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walk..

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Persisting adverse body composition changes 2 years after cessation of androgen deprivation therapy for localised prostate cancer

Ada S Cheung, Alistair J Tinson, Stefan Milevski, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann

2018-07-01

OBJECTIVE: Hypogonadism from androgen deprivation therapy (ADT) for prostate cancer causes adverse body composition changes associ..

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Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer

Ada S Cheung, Casey de Rooy, Itamar Levinger, Kesha Rana, Michele V Clarke, Jackie M How, Andrew Garnham, Catriona McLean, Jeffrey D Zajac, Rachel A Davey, Mathis Grossmann

2017-11-01

Androgen deprivation therapy (ADT) decreases muscle mass and function but no human studies have investigated the underlying geneti..

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Effects of androgen deprivation therapy on telomere length

Ada S Cheung, Bu B Yeap, Rudolf Hoermann, Jennie Hui, John P Beilby, Mathis Grossmann

2017-10-01

OBJECTIVE: Recent evidence suggests that androgens either directly or via aromatisation to oestradiol may regulate telomere length..

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Hypothalamic-Pituitary-Thyroid Axis Set Point Alterations Are Associated With Body Composition in Androgen-Deprived Men

Rudolf Hoermann, Ada S Cheung, Michele Milne, Mathis Grossmann

2017-07-01

OBJECTIVE: Androgen deprivation therapy (ADT) given to men with prostate cancer is associated with metabolically adverse changes i..

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Quality of life decrements in men with prostate cancer undergoing androgen deprivation therapy

Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

2017-03-01

OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospecti..

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Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case-control study

Ada S Cheung, Hans Gray, Anthony G Schache, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann

2017-02-01

BACKGROUND: Although muscle mass declines with testosterone deficiency in men, previous studies of muscle function have not demons..

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Relationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer

Ada S Cheung, Rudolf Hoermann, Philippe Dupuis, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

2016-09-01

OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with insulin resistance and frailty, controlled prospectiv..

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Correlation of visceral adipose tissue measured by Lunar Prodigy dual X-ray absorptiometry with MRI and CT in older men

AS Cheung, C de Rooy, R Hoermann, EJ Gianatti, EJ Hamilton, G Roff, JD Zajac, M Grossmann

2016-08-01

Quantification of abdominal visceral adipose tissue (VAT) is important to understand obesity-related comorbidities. We hypothesize..

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Impact of Androgen Deprivation Therapy on High-level Physical Performance

Mathis Grossmann, Ada S Cheung

2016-06-01

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Targeting muscle signaling pathways to minimize adverse effects of androgen deprivation

Casey de Rooy, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung

2016-01-01

Androgen deprivation therapy (ADT) is a highly effective treatment used in ∼30% of men with prostate cancer. Adverse effects of AD..

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Muscle and bone effects of androgen deprivation therapy: current and emerging therapies

Ada S Cheung, Jeffrey D Zajac, Mathis Grossmann

2014-10-01

Prostate cancer and treatment with androgen deprivation therapy (ADT) affect significant numbers of the male population. Endocrine..

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Testosterone levels increase in association with recovery from acute fracture in men

AS Cheung, S Baqar, R Sia, R Hoermann, S Iuliano-Burns, TDT Vu, C Chiang, EJ Hamilton, E Gianatti, E Seeman, JD Zajac, M Grossmann

2014-08-01

UNLABELLED: In this longitudinal case-control study, acute fracture was associated with low serum testosterone, which was transien..

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Androgens and prostate cancer; pathogenesis and deprivation therapy

Mathis Grossmann, Ada S Cheung, Jeffrey D Zajac

2013-08-01

Although androgen receptor signaling is critical for prostate cancer growth and survival, evidence supporting a favorable risk-ben..

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Cardiovascular risk and bone loss in men undergoing androgen deprivation therapy for non-metastatic prostate cancer: implementation of standardized management guidelines

AS Cheung, D Pattison, I Bretherton, R Hoermann, D Lim Joon, E Ho, T Jenkins, EJ Hamilton, K Bate, I Chan, JD Zajac, M Grossmann

2013-07-01

Our objective was to evaluate the effectiveness of implementing standardized guidelines to mitigate metabolic and bone side effect..

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