IDENTIFICATION OF A PLASMA BORNE FACTOR OF REMOTE ISCHAEMIC PRECONDITIONING AND ITS EFFECT ON THE PROTEOME AFTER HEART SURGERY
Grant number: 1017734 | Funding period: 2011 - 2014
During a heart operation, a patient needs a heart-lung bypass machine to supply blood to their body. We are interested in looking at a new therapy called Remote Ischaemic Preconditioning that may decrease the damaging effects of this heart-lung bypass machine. This therapy is applied using a blood pressure cuff before surgery and protects the organs. We want to see if this protects children who are having surgery for the first time and identify proteins in the blood that may be involved.
Related publications (3)
Cardiopulmonary bypass changes the plasma proteome in children undergoing tetralogy of Fallot repair
M Hepponstall, V Ignjatovic, S Binos, C Attard, V Karlaftis, Y d'Udekem, P Monagle, IE Konstantinov
INTRODUCTION: Cardiopulmonary bypass (CPB) can be associated with deleterious clinical effects. However, the impact of CPB on infl..
Remote Ischemic Preconditioning (RIPC) Modifies the Plasma Proteome in Children Undergoing Repair of Tetralogy of Fallot: A Randomized Controlled Trial
Michele Hepponstall, Vera Ignjatovic, Steve Binos, Chantal Attard, Vasiliki Karlaftis, Yves d'Udekem, Paul Monagle, Igor E Konstantinov
BACKGROUND: Remote ischemic preconditioning (RIPC) has been applied in paediatric cardiac surgery. We have demonstrated that RIPC ..
Remote Ischemic Preconditioning (RIPC) Modifies Plasma Proteome in Humans
Michele Hepponstall, Vera Ignjatovic, Steve Binos, Paul Monagle, Bryn Jones, Michael HH Cheung, Yves d'Udekem, Igor E Konstantinov
Remote Ischemic Preconditioning (RIPC) induced by brief episodes of ischemia of the limb protects against multi-organ damage by is..