THE ROLE OF ANGIOTENSIN-(1-7), ANGIOTENSIN CONVERTING ENZYME-2 AND THE MAS RECEPTOR IN LIVER FIBROSIS AND THE DEVELOPMENT AND MAINTENANCE OF PORTAL HYPERTENSION

Abstract

Chronic liver disease is widespread in our community, and is increasing due to fatty liver disease and viral hepatitis. Liver disease leads to permanent liver scarring, liver cancer and other life-threatening complications. This research investigates the role of a hormone system called the renin-angiotensin system in liver disease, and investigated the use of drugs that act on this system for the prevention and treatment of liver scarring and these complications.