Promoting Central Nervous System Myelination

Grant number: 628761 | Funding period: 2010 - 2013

Completed

Abstract

Multiple Sclerosis (MS) is the most common neurological cause of disability in young adult Australians. The cause of MS is unknown and therapies are limited to reducing inflammation, which does not address the major problem of the disease: loss of myelin. This project directly investigates how myelin is formed and will identify key mechanisms in this process, which may eventually be developed into treatments for diseases such as MS.

Related publications (6)

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Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination

H Peckham, L Giuffrida, R Wood, D Gonsalvez, A Ferner, TJ Kilpatrick, SS Murray, J Xiao

2016-02-01

Fyn, a member of the Src family of nonreceptor tyrosine kinases, promotes central nervous system myelination during development; h..

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Production and use of lentivirus to selectively transduce primary oligodendrocyte precursor cells for in vitro myelination assays

HM Peckham, AH Ferner, L Giuffrida, SS Murray, J Xiao

2015-01-12

Myelination is a complex process that involves both neurons and the myelin forming glial cells, oligodendrocytes in the central ne..

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A small peptide mimetic of brain-derived neurotrophic factor promotes peripheral myelination

J Xiao, RA Hughes, JY Lim, AW Wong, JJ Ivanusic, AH Ferner, TJ Kilpatrick, SS Murray

2013-05-01

The expression of the neurotrophins and their receptors is essential for peripheral nervous system development and myelination. We..

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Oligodendroglial expression of TrkB independently regulates myelination and progenitor cell proliferation

AW Wong, J Xiao, D Kemper, TJ Kilpatrick, SS Murray

2013-03-13

The neurotrophin brain-derived neurotrophic factor (BDNF) has been implicated in regulating CNS myelination. BDNF mutant mice exhi..

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Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro

J Xiao, AH Ferner, AW Wong, M Denham, TJ Kilpatrick, SS Murray

2012-09-01

Multiple extracellular factors have been implicated in orchestrating myelination of the CNS; however, less is known about the intr..

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Brain-derived neurotrophic factor promotes central nervous system myelination via a direct effect upon oligodendrocytes

J Xiao, AW Wong, MM Willingham, M Van Den Buuse, TJ Kilpatrick, SS Murray

2011-03-01

The extracellular factors that are responsible for inducing myelination in the central nervous system (CNS) remain elusive. We inv..

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