ANTIGEN PRESENTATION RECOGNITION AND THE IMMUNE SYSTEM
Grant number: 1016629 | Funding period: 2012 - 2016
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Related publications (19)
Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1
Lauren J Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish EG McWilliam, Maria L Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D Andrews, David H McDermott, Philip M Murphy, Jerome Le Nours, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Jose A Villadangos, Matthew C Cook, Stephen J Turner, Martin S Davey
The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are ..
alpha-Glucuronosyl and alpha-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi
Satvika Burugupalli, Catarina F Almeida, Dylan GM Smith, Sayali Shah, Onisha Patel, Jamie Rossjohn, Adam P Uldrich, Dale I Godfrey, Spencer J Williams
<p>Microbial α-glycosyl diacylglycerides when presented by the antigen presenting molecule CD1d are recognized by both classical t..
A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1
Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
Catarina F Almeida, Srinivasan Sundararaj, Jerome Le Nours, T Praveena, Benjamin Cao, Satvika Burugupalli, Dylan GM Smith, Onisha Patel, Manfred Brigl, Daniel G Pellicci, Spencer J Williams, Adam P Uldrich, Dale I Godfrey, Jamie Rossjohn
Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an und..
Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality
Timothy SC Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J Pediongco, Bronwyn S Meehan, Lyudmila Kostenko, Stephen J Turner, Alexandra J Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey
Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells
Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Hui-Fern Koay, Bronwyn Meehan, Zhe Zhao, Troi Pediongco, Mai Shi, Tianyuan Zhu, Bingjie Wang, Lars Kjer-Nielsen, Sidonia BG Eckle, Jamie Rossjohn, David P Fairlie, Dale I Godfrey, Richard A Strugnell, James McCluskey, Alexandra J Corbett
This unit describes the utility of various mouse models of infection and immunization for studying mucosal-associated invariant T ..
MAIT cells protect against pulmonary Legionella longbeachae infection
Huimeng Wang, Criselle D'Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J Pediongco, Sidonia BG Eckle, Bronwyn S Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Yoichiro Iwakura, Jennifer M Gunnersen, Andrew W Stent, Dale I Godfrey, Jamie Rossjohn, Glen P Westall, Lars Kjer-Nielsen
Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals
Z Chen, H Wang, C D'Souza, S Sun, L Kostenko, SBG Eckle, BS Meehan, DC Jackson, RA Strugnell, H Cao, N Wang, DP Fairlie, L Liu, DI Godfrey, J Rossjohn, J McCluskey, AJ Corbett
Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition
Philippa M Saunders, Phillip Pymm, Gabriella Pietra, Victoria A Hughes, Corinne Hitchen, Geraldine M O'Connor, Fabrizio Loiacono, Jacqueline Widjaja, David A Price, Michela Falco, Maria Cristina Mingari, Lorenzo Moretta, Daniel W McVicar, Jamie Rossjohn, Andrew G Brooks, Julian P Vivian
Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites
Isaac G Sakala, Lars Kjer-Nielsen, Christopher S Eickhoff, Xiaoli Wang, Azra Blazevic, Ligong Liu, David P Fairlie, Jamie Rossjohn, James McCluskey, Daved H Fremont, Ted H Hansen, Daniel F Hoft
Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers
Azad Rahimpour, Hui Fern Koay, Anselm Enders, Rhiannon Clanchy, Sidonia BG Eckle, Bronwyn Meehan, Zhenjun Chen, Belinda Whittle, Ligong Liu, David P Fairlie, Chris C Goodnow, James McCluskey, Jamie Rossjohn, Adam P Uldrich, Daniel G Pellicci, Dale I Godfrey
CD8( ) T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria
Lei Shong Lau, Daniel Fernandez-Ruiz, Vanessa Mollard, Angelika Sturm, Michelle A Neller, Anton Cozijnsen, Julia L Gregory, Gayle M Davey, Claerwen M Jones, Yi-Hsuan Lin, Ashraful Haque, Christian R Engwerda, Catherine Q Nie, Diana S Hansen, Kenneth M Murphy, Anthony T Papenfuss, John J Miles, Scott R Burrows, Tania de Koning-Ward, Geoffrey I McFadden