ANTIGEN PRESENTATION RECOGNITION AND THE IMMUNE SYSTEM
Grant number: 1016629 | Funding period: 2012 - 2016
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Related publications (7)
Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1
Lauren J Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish EG McWilliam, Maria L Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D Andrews, David H McDermott, Philip M Murphy, Jerome Le Nours, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Jose A Villadangos, Matthew C Cook, Stephen J Turner, Martin S Davey
The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are ..
Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition
Philippa M Saunders, Phillip Pymm, Gabriella Pietra, Victoria A Hughes, Corinne Hitchen, Geraldine M O'Connor, Fabrizio Loiacono, Jacqueline Widjaja, David A Price, Michela Falco, Maria Cristina Mingari, Lorenzo Moretta, Daniel W McVicar, Jamie Rossjohn, Andrew G Brooks, Julian P Vivian
Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites
Isaac G Sakala, Lars Kjer-Nielsen, Christopher S Eickhoff, Xiaoli Wang, Azra Blazevic, Ligong Liu, David P Fairlie, Jamie Rossjohn, James McCluskey, Daved H Fremont, Ted H Hansen, Daniel F Hoft
CD8( ) T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria
Lei Shong Lau, Daniel Fernandez-Ruiz, Vanessa Mollard, Angelika Sturm, Michelle A Neller, Anton Cozijnsen, Julia L Gregory, Gayle M Davey, Claerwen M Jones, Yi-Hsuan Lin, Ashraful Haque, Christian R Engwerda, Catherine Q Nie, Diana S Hansen, Kenneth M Murphy, Anthony T Papenfuss, John J Miles, Scott R Burrows, Tania de Koning-Ward, Geoffrey I McFadden