IMMUNE REGULATION EFFECTOR FUNCTION AND THERAPY
Grant number: 1013667 | Funding period: 2012 - 2016
We seek to understand how white blood cells detect and destroy disease, and how molecules of the immune system punch holes in diseased cells. We wish to learn how cancer can sometimes evade the immune system. Our work will also find out how some common treatments for cancer, like chemotherapy, can be used to boost the immune system and eliminate tumours. Through knowledge gained from these studies, we aim to develop new therapies that can help patients with devastating diseases like cancer.
Related publications (63)
Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1
Lauren J Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish EG McWilliam, Maria L Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D Andrews, David H McDermott, Philip M Murphy, Jerome Le Nours, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Jose A Villadangos, Matthew C Cook, Stephen J Turner, Martin S Davey
The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are ..
alpha-Glucuronosyl and alpha-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi
Satvika Burugupalli, Catarina F Almeida, Dylan GM Smith, Sayali Shah, Onisha Patel, Jamie Rossjohn, Adam P Uldrich, Dale I Godfrey, Spencer J Williams
Natural killer T cells express T cell receptors (TCRs) that recognize glycolipid antigens in association with the antigen-presenti..
A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1
Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
Catarina F Almeida, Srinivasan Sundararaj, Jerome Le Nours, T Praveena, Benjamin Cao, Satvika Burugupalli, Dylan GM Smith, Onisha Patel, Manfred Brigl, Daniel G Pellicci, Spencer J Williams, Adam P Uldrich, Dale I Godfrey, Jamie Rossjohn
Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an und..
Dual Modifications of alpha-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
Divya Chennamadhavuni, Noemi Alejandra Saavedra-Avila, Leandro J Carreno, Matthew J Guberman-Pfeffer, Pooja Arora, Yongqing Tang, Hui-Fern Koay, Dale I Godfrey, Santosh Keshipeddy, Stewart K Richardson, Srinivasan Sundararaj, Jae Ho Lo, Xiangshu Wen, Jose A Gascon, Weiming Yuan, Jamie Rossjohn, Jerome Le Nours, Steven A Porcelli, Amy R Howell
Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications fo..
Human blood MAIT cell subsets defined using MR1 tetramers
Nicholas A Gherardin, Michael NT Souter, Hui-Fern Koay, Kirstie M Mangas, Torsten Seemann, Timothy P Stinear, Sidonia BG Eckle, Stuart P Berzins, Yves d'Udekem, Igor E Konstantinov, David P Fairlie, David S Ritchie, Paul J Neeson, Daniel G Pellicci, Adam P Uldrich, James McCluskey, Dale I Godfrey
Mucosal-associated invariant T (MAIT) cells represent up to 10% of circulating human T cells. They are usually defined using combi..
γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.
Ayano C Kohlgruber, Shani T Gal-Oz, Nelson M LaMarche, Moto Shimazaki, Danielle Duquette, Hui-Fern Koay, Hung N Nguyen, Amir I Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Adam P Uldrich, Dale I Godfrey, Alexander S Banks, Tal Shay, Michael B Brenner, Lydia Lynch
γδ T cells are situated at barrier sites and guard the body from infection and damage. However, little is known about their roles ..
Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma
Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey
Mucosal-associated invariant T (MAIT) cells are T cells that recognise vitamin-B derivative Ag presented by the MHC-related-protei..
Augmenting Influenza-Specific T Cell Memory Generation with a Natural Killer T Cell-Dependent Glycolipid-Peptide Vaccine
Regan J Anderson, Jasmine Li, Lukasz Kedzierski, Benjamin J Compton, Colin M Hayman, Taryn L Osmond, Ching-wen Tang, Kathryn J Farrand, Hui-Fern Koay, Catarina Filipa Dos Santos Sa E Almeida, Lauren R Holz, Geoffrey M Williams, Margaret A Brimble, Zhongfang Wang, Marios Koutsakos, Katherine Kedzierska, Dale I Godfrey, Ian F Hermans, Stephen J Turner, Gavin F Painter
The development of a universal vaccine for influenza A virus (IAV) that does not require seasonal modification is a long-standing ..
PTPN2 regulates T cell lineage commitment and alpha beta versus gamma delta specification
Florian Wiede, Jarrod A Dudakov, Kun-Hui Lu, Garron T Dodd, Tariq Butt, Dale I Godfrey, Andreas Strasser, Richard L Boyd, Tony Tiganis
In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T..
Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface
Patrick J Brennan, Tan-Yun Cheng, Daniel G Pellicci, Gerald FM Watts, Natacha Veerapen, David C Young, Jamie Rossjohn, Gurdyal S Besra, Dale I Godfrey, Michael B Brenner, D Branch Moody
Glycolipid antigens recognized by αβ T-cell receptors (TCRs) drive the activation of invariant natural killer T (iNKT) cells, a sp..
Real-time visualization of perforin nanopore assembly
Carl Leung, Adrian W Hodel, Amelia J Brennan, Natalya Lukoyanova, Sharon Tran, Colin M House, Stephanie C Kondos, James C Whisstock, Michelle A Dunstone, Joseph A Trapani, Ilia Voskoboinik, Helen R Saibil, Bart W Hoogenboom
Perforin is a key protein of the vertebrate immune system. Secreted by cytotoxic lymphocytes as soluble monomers, perforin can sel..
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis
Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke
The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive ..
A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage
Hui-Fern Koay, Nicholas A Gherardin, Anselm Enders, Liyen Loh, Laura K Mackay, Catarina F Almeida, Brendan E Russ, Claudia A Nold-Petry, Marcel F Nold, Sammy Bedoui, Zhenjun Chen, Alexandra J Corbett, Sidonia BG Eckle, Bronwyn Meehan, Yves d'Udekem, Igor E Konstantinov, Martha Lappas, Ligong Liu, Chris C Goodnow, David P Fairlie
Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives presented by the antigen-presenting mole..
CIS is a potent checkpoint in NK cell-mediated tumor immunity
Rebecca B Delconte, Tatiana B Kolesnik, Laura F Dagley, Jai Rautela, Wei Shi, Eva M Putz, Kimberley Stannard, Jian-Guo Zhang, Charis Teh, Matt Firth, Takashi Ushiki, Christopher E Andoniou, Mariapia A Degli-Esposti, Phillip P Sharp, Caroline E Sanvitale, Giuseppe Infusini, Nicholas PD Liau, Edmond M Linossi, Christopher J Burns, Sebastian Carotta
The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhib..
TGF-beta inhibits the activation and functions of NK cells by repressing the mTOR pathway
Sebastien Viel, Antoine Marcais, Fernando Souza-Fonseca Guimaraes, Roisin Loftus, Jessica Rabilloud, Morgan Grau, Sophie Degouve, Sophia Djebali, Amelien Sanlaville, Emily Charrier, Jacques Bienvenu, Julien C Marie, Christophe Caux, Jacqueline Marvel, Liam Town, Nicholas D Huntington, Laurent Bartholin, David Finlay, Mark J Smyth, Thierry Walzer
Transforming growth factor-β (TGF-β) is a major immunosuppressive cytokine that maintains immune homeostasis and prevents autoimmu..
Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens
Jerome Le Nours, T Praveena, Daniel G Pellicci, Nicholas A Gherardin, Fiona J Ross, Ricky T Lim, Gurdyal S Besra, Santosh Keshipeddy, Stewart K Richardson, Amy R Howell, Stephanie Gras, Dale I Godfrey, Jamie Rossjohn, Adam P Uldrich
Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. H..
Reprogramming the tumor microenvironment to enhance adoptive cellular therapy
Paul A Beavis, Clare Y Slaney, Michael H Kershaw, David Gyorki, Paul J Neeson, Phillip K Darcy
The frontiers of cancer immunotherapy are extending in terms of both the range of cancer types that can potentially be targeted an..
Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition
Nicholas A Gherardin, Andrew N Keller, Rachel E Woolley, Jerome Le Nours, David S Ritchie, Paul J Neeson, Richard W Birkinshaw, Sidonia BG Eckle, John N Waddington, Ligong Liu, David P Fairlie, Adam P Uldrich, Daniel G Pellicci, James McCluskey, Dale I Godfrey, Jamie Rossjohn
A characteristic of mucosal-associated invariant T (MAIT) cells is the expression of TRAV1-2(+) T cell receptors (TCRs) that are a..
Human autoreactive T cells recognize CD1b and phospholipids
Ildiko Van Rhijn, Twan van Berlo, Tamara Hilmenyuk, Tan-Yun Cheng, Benjamin J Wolf, Raju VV Tatituri, Adam P Uldrich, Giorgio Napolitani, Vincenzo Cerundolo, John D Altman, Peter Willemsen, Shouxiong Huang, Jamie Rossjohn, Gurdyal S Besra, Michael B Brenner, Dale I Godfrey, D Branch Moody
In contrast with the common detection of T cells that recognize MHC, CD1a, CD1c, or CD1d proteins, CD1b autoreactive T cells have ..
Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells
Sidonia BG Eckle, Alexandra J Corbett, Andrew N Keller, Zhenjun Chen, Dale I Godfrey, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Jamie Rossjohn, James McCluskey
Vitamin B2 (riboflavin) is essential for metabolic functions and is synthesized by many bacteria, yeast, and plants, but not by ma..
Antigen Specificity of Type I NKT Cells Is Governed by TCR beta-Chain Diversity
Garth Cameron, Daniel G Pellicci, Adam P Uldrich, Gurdyal S Besra, Petr Illarionov, Spencer J Williams, Nicole L La Gruta, Jamie Rossjohn, Dale I Godfrey
NKT cells recognize lipid-based Ags presented by CD1d. Type I NKT cells are often referred to as invariant owing to their mostly i..
Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic
Connie PM Duong, Carmen SM Yong, Michael H Kershaw, Clare Y Slaney, Phillip K Darcy
The immune system plays a critical role in the elimination and suppression of pathogens. Although the endogenous immune system is ..
Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells
Benjamin J Wolf, Raju VV Tatituri, Catarina F Almeida, Jerome Le Nours, Veemal Bhowruth, Darryl Johnson, Adam P Uldrich, Fong-Fu Hsu, Manfred Brigl, Gurdyal S Besra, Jamie Rossjohn, Dale I Godfrey, Michael B Brenner
Semi-invariant/type I NKT cells are a well-characterized CD1d-restricted T cell subset. The availability of potent Ags and tetrame..
Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers
Azad Rahimpour, Hui Fern Koay, Anselm Enders, Rhiannon Clanchy, Sidonia BG Eckle, Bronwyn Meehan, Zhenjun Chen, Belinda Whittle, Ligong Liu, David P Fairlie, Chris C Goodnow, James McCluskey, Jamie Rossjohn, Adam P Uldrich, Daniel G Pellicci, Dale I Godfrey
Studies on the biology of mucosal-associated invariant T cells (MAIT cells) in mice have been hampered by a lack of specific reage..
Immunosurveillance and therapy of multiple myeloma are CD226 dependent
Camille Guillerey, Lucas Ferrari de Andrade, Slavica Vuckovic, Kim Miles, Shin Foong Ngiow, Michelle CR Yong, Michele WL Teng, Marco Colonna, David S Ritchie, Martha Chesi, P Leif Bergsagel, Geoffrey R Hil, Mark J Smyth, Ludovic Martinet
Multiple myeloma (MM) is an age-dependent hematological malignancy. Evaluation of immune interactions that drive MM relies on in v..
DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation
Ludovic Martinet, Lucas Ferrari De Andrade, Camille Guillerey, Jason S Lee, Jing Liu, Fernando Souza-Fonseca-Guimaraes, Dana S Hutchinson, Tatiana B Kolesnik, Sandra E Nicholson, Nicholas D Huntington, Mark J Smyth
Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. How..
alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands
Richard W Birkinshaw, Daniel G Pellicci, Tan-Yun Cheng, Andrew N Keller, Maria Sandoval-Romero, Stephanie Gras, Annemieke de Jong, Adam P Uldrich, D Branch Moody, Dale I Godfrey, Jamie Rossjohn
A central paradigm in αβ T cell-mediated immunity is the simultaneous co-recognition of antigens and antigen-presenting molecules ..
MAIT cells are depleted early but retain functional cytokine expression in HIV infection
Caroline S Fernandez, Thakshila Amarasena, Anthony D Kelleher, Jamie Rossjohn, James McCluskey, Dale I Godfrey, Stephen J Kent
Mucosal-associated invariant T (MAIT) cells home to mucosal sites and exert antimicrobial activity against bacteria and other micr..
Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression
Paul A Beavis, Clare Y Slaney, Michael H Kershaw, Paul J Neeson, Phillip K Darcy
Strategies aimed at stimulating the immune system against cancer have signaled a new era for designing new effective therapies for..
Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib
Paul J Neeson, Andy K Hsu, Yin R Chen, Heloise M Halse, Joanna Loh, Reece Cordy, Kate Fielding, Joanne Davis, Josh Noske, Alex J Davenport, Camilla A Lindqvist-Gigg, Robin Humphreys, Tsin Tai, H Miles Prince, Joseph A Trapani, Mark J Smyth, David S Ritchie
There is increasing evidence that some cancer therapies can promote tumor immunogenicity to boost the endogenous antitumor immune ..
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T-reg cells and macrophages in adipose tissue
Lydia Lynch, Xavier Michelet, Sai Zhang, Patrick J Brennan, Ashley Moseman, Chantel Lester, Gurdyal Besra, Emilie E Vomhof-Dekrey, Mike Tighe, Hui-Fern Koay, Dale I Godfrey, Elizabeth A Leadbetter, Derek B Sant'Angelo, Ulrich von Andrian, Michael B Brenner
Invariant natural killer T cells (iNKT cells) are lipid-sensing innate T cells that are restricted by the antigen-presenting molec..
The molecular bases of delta/alpha beta T cell-mediated antigen recognition
Daniel G Pellicci, Adam P Uldrich, Jerome Le Nours, Fiona Ross, Eric Chabrol, Sidonia BG Eckle, Renate de Boer, Ricky T Lim, Kirsty McPherson, Gurdyal Besra, Amy R Howell, Lorenzo Moretta, James McCluskey, Mirjam HM Heemskerk, Stephanie Gras, Jamie Rossjohn, Dale I Godfrey
αβ and γδ T cells are disparate T cell lineages that can respond to distinct antigens (Ags) via the use of the αβ and γδ T cell Ag..
The glucocorticoid receptor 1A3 promoter correlates with high sensitivity to glucocorticoid-induced apoptosis in human lymphocytes
Douglas R Liddicoat, Konstantinos Kyparissoudis, Stuart P Berzins, Timothy J Cole, Dale I Godfrey
Glucocorticoids (GCs) are powerful inhibitors of inflammation and immunity. Although glucocorticoid-induced cell death (GICD) is a..
Foxp3 Expression in Macrophages Associated with RENCA Tumors in Mice
Christel Devaud, Carmen SM Yong, Liza B John, Jennifer A Westwood, Connie PM Duong, Colin M House, Delphine Denoyer, Jason Li, Phillip K Darcy, Michael H Kershaw
The transcription factor Foxp3 represents the most specific functional marker of CD4+ regulatory T cells (TRegs). However, previou..
IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival
KE Webster, H-O Kim, K Kyparissoudis, TM Corpuz, GV Pinget, AP Uldrich, R Brink, GT Belz, J-H Cho, DI Godfrey, J Sprent
Natural killer T (NKT) cells are innate-like T cells that rapidly recognize pathogens and produce cytokines that shape the ensuing..
The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions
Christopher J Chan, Ludovic Martinet, Susan Gilfillan, Fernando Souza-Fonseca-Guimaraes, Melvyn T Chow, Liam Town, David S Ritchie, Marco Colonna, Daniel M Andrews, Mark J Smyth
CD96, CD226 (DNAM-1) and TIGIT belong to an emerging family of receptors that interact with nectin and nectin-like proteins. CD226..
CD1d-lipid antigen recognition by the gamma delta TCR
Adam P Uldrich, Jerome Le Nours, Daniel G Pellicci, Nicholas A Gherardin, Kirsty G McPherson, Ricky T Lim, Onisha Patel, Travis Beddoe, Stephanie Gras, Jamie Rossjohn, Dale I Godfrey
The T cell repertoire comprises αβ and γδ T cell lineages. Although it is established how αβ T cell antigen receptors (TCRs) inter..
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
Rangsima Reantragoon, Alexandra J Corbett, Isaac G Sakala, Nicholas A Gherardin, John B Furness, Zhenjun Chen, Sidonia BG Eckle, Adam P Uldrich, Richard W Birkinshaw, Onisha Patel, Lyudmila Kostenko, Bronwyn Meehan, Katherine Kedzierska, Ligong Liu, David P Fairlie, Ted H Hansen, Dale I Godfrey, Jamie Rossjohn, James McCluskey, Lars Kjer-Nielsen
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) α-chain, TRAV1-2-TRAJ33, and are ..
DOCK8 is critical for the survival and function of NKT cells
Greg Crawford, Anselm Enders, Uzi Gileadi, Sanda Stankovic, Qian Zhang, Teresa Lambe, Tanya L Crockford, Helen E Lockstone, Alexandra Freeman, Peter D Arkwright, Joanne M Smart, Cindy S Ma, Stuart G Tangye, Christopher C Goodnow, Vincenzo Cerundolo, Dale I Godfrey, Helen C Su, Katrina L Randall, Richard J Cornall
Patients with the dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome suffer from recurrent viral and bacterial infection..
CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
Sherene Loi, Sandra Pommey, Benjamin Haibe-Kains, Paul A Beavis, Phillip K Darcy, Mark J Smyth, John Stagg
Using gene-expression data from over 6,000 breast cancer patients, we report herein that high CD73 expression is associated with a..
A conserved human T cell population targets mycobacterial antigens presented by CD1b
Ildiko Van Rhijn, Anne Kasmar, Annemieke de Jong, Stephanie Gras, Mugdha Bhati, Marieke E Doorenspleet, Niek de Vries, Dale I Godfrey, John D Altman, Wilco de Jager, Jamie Rossjohn, D Branch Moody
Human T cell antigen receptors (TCRs) pair in millions of combinations to create complex and unique T cell repertoires for each pe..
Ex-vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4( ) and CD4(-) subsets
AC Chan, E Leeansyah, A Cochrane, Y d'Udekem d'Acoz, D Mittag, LC Harrison, DI Godfrey, SP Berzins
Our understanding of human type 1 natural killer T (NKT) cells has been heavily dependent on studies of cells from peripheral bloo..
CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells
Joseph P Sanderson, Patrick J Brennan, Salah Mansour, Gediminas Matulis, Onisha Patel, Nikolai Lissin, Dale I Godfrey, Kazuyoshi Kawahara, Ulrich Zaehringer, Jamie Rossjohn, Michael B Brenner, Stephan D Gadola
Isoglobotrihexosylceramide (iGb3) has been identified as a potent CD1d-presented self-antigen for mouse invariant natural killer T..
Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs
Raju VV Tatituri, Gerald FM Watts, Veemal Bhowruth, Nathaniel Barton, Alissa Rothchild, Fong-Fu Hsu, Catarina F Almeida, Liam R Cox, Lothar Eggeling, Susanna Cardell, Jamie Rossjohn, Dale I Godfrey, Samuel M Behar, Gurdyal S Besra, Michael B Brenner, Manfred Brigl
CD1d-restricted natural killer T (NKT) cells include two major subgroups. The most widely studied are Vα14Jα18(+) invariant NKT (i..
ZBTB7B (Th-POK) Regulates the Development of IL-17-Producing CD1d-Restricted Mouse NKT Cells
Anselm Enders, Sanda Stankovic, Charis Teh, Adam P Uldrich, Mehmet Yabas, Torsten Juelich, John A Altin, Sandra Frankenreiter, Hannes Bergmann, Carla M Roots, Konstantinos Kyparissoudis, Chris C Goodnow, Dale I Godfrey
CD1d-dependent NKT cells represent a heterogeneous family of effector T cells including CD4(+)CD8(-) and CD4(-)CD8(-) subsets that..
MR1 presents microbial vitamin B metabolites to MAIT cells
Lars Kjer-Nielsen, Onisha Patel, Alexandra J Corbett, Jerome Le Nours, Bronwyn Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, Lyudmila Kostenko, Rangsima Reantragoon, Nicholas A Williamson, Anthony W Purcell, Nadine L Dudek, Malcolm J McConville, Richard AJ O'Hair, George N Khairallah, Dale I Godfrey, David P Fairlie, Jamie Rossjohn, James McCluskey
Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptide- and lipid-based ..
Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex
Kwok S Wun, Fiona Ross, Onisha Patel, Gurdyal S Besra, Steven A Porcelli, Stewart K Richardson, Santosh Keshipeddy, Amy R Howell, Dale I Godfrey, Jamie Rossjohn
Human and mouse type I natural killer T (NKT) cells respond to a variety of CD1d-restricted glycolipid antigens (Ags), with their ..
Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor
Onisha Patel, Daniel G Pellicci, Stephanie Gras, Maria L Sandoval-Romero, Adam P Uldrich, Thierry Mallevaey, Andrew J Clarke, Jerome Le Nours, Alex Theodossis, Susanna L Cardell, Laurent Gapin, Dale I Godfrey, Jamie Rossjohn
Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen..
CD73-Deficient Mice Are Resistant to Carcinogenesis
John Stagg, Paul A Beavis, Upulie Divisekera, Mira CP Liu, Andreas Moeller, Phillip K Darcy, Mark J Smyth
CD73 is a cell surface 5'-nucleotidase that converts AMP to adenosine, an immune suppressive molecule. CD73 may promote immune esc..