AUSTRALIAN BASED BIOMEDICAL FELLOWSHIP
Grant number: 490995 | Funding period: 2011 - 2012
The endometrium (lining of the uterus) undergoes breakdown and re-growth each month as part of the menstrual cycle. This restorative process is not well understood. For the first time stem cells have been identified within human endometrium that are likely to be responsible for its remarkable regeneration. The aim of this project is to identify stem cells within the mouse endometrium, to use as a model to understand how the endometrium restores each month after menstruation.
Related publications (9)
Plasma MIC-1 and PAPP-A Levels Are Decreased among Women Presenting to an Early Pregnancy Assessment Unit, Have Fetal Viability Confirmed but Later Miscarry
Tu'uhevaha J Kaitu'u-Lino, Katerina Bambang, Joseph Onwude, Richard Hiscock, Justin Konje, Stephen Tong
BACKGROUND: We have recently shown first trimester Macrophage inhibitory cytokine-1 (MIC-1) and Pregnancy Associated Plasma Protei..
Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua
Tu'uhevaha J Kaitu'u-Lino, Louie Ye, Laura Tuohey, Evdokia Dimitriadis, Judith Bulmer, Peter Rogers, Ellen Menkhorst, Michelle Van Sinderen, Jane E Girling, Natalie Hannan, Stephen Tong
STUDY QUESTION: What is the nature of cellular Corin expression in human gestational tissues? SUMMARY ANSWER: CORIN is expressed i..
Placental Specific mRNA in the Maternal Circulation Are Globally Dysregulated in Pregnancies Complicated by Fetal Growth Restriction
Clare L Whitehead, Susan P Walker, Louie Ye, Sonali Mendis, Tu'uhevaha J Kaitu'u-Lino, Martha Lappas, Stephen Tong
CONTEXT: Fetal growth restriction (FGR) is a leading cause of perinatal mortality, yet no reliable screening test exists. Placenta..
Targeted Nanoparticle Delivery of Doxorubicin Into Placental Tissues to Treat Ectopic Pregnancies
Tu'uhevaha J Kaitu'u-Lino, Scott Pattison, Louie Ye, Laura Tuohey, Pavel Sluka, Jennifer MacDiarmid, Himanshu Brahmbhatt, Terrence Johns, Andrew W Horne, Jeremy Brown, Stephen Tong
Abnormal trophoblast growth can cause life-threatening disorders such as ectopic pregnancy, choriocarcinoma, and placenta accreta...
MMP-15 Is Upregulated in Preeclampsia, but Does Not Cleave Endoglin to Produce Soluble Endoglin
Tu'uhevaha J Kaitu'u-Lino, Kirsten Palmer, Laura Tuohey, Louie Ye, Stephen Tong
Preeclampsia is a major pregnancy complication, characterized by severe endothelial dysfunction, hypertension and maternal end-org..
Identification of Label-Retaining Perivascular Cells in a Mouse Model of Endometrial Decidualization, Breakdown, and Repair
Tu'uhevaha J Kaitu'u-Lino, Louie Ye, Lois A Salamonsen, Jane E Girling, Caroline E Gargett
The human endometrium is incredibly dynamic, undergoing monthly cycles of growth and regression during a woman's reproductive life..
MMP-14 Is Expressed in Preeclamptic Placentas and Mediates Release of Soluble Endoglin
Tu'uhevaha J Kaitu'u-Lino, Kirsten R Palmer, Clare L Whitehead, Elizabeth Williams, Martha Lappas, Stephen Tong
Soluble endoglin is an anti-angiogenic protein that is released from the placenta and contributes to both maternal endothelial dys..
Serum Concentrations of Soluble Flt-1 Are Decreased among Women with a Viable Fetus and No Symptoms of Miscarriage Destined for Pregnancy Loss
Tu'uhevaha J Kaitu'u-Lino, Clare L Whitehead, Gene-Lyn Ngian, Michael Permezel, Stephen Tong
Miscarriage is the most common complication of pregnancy. Pre-clinical miscarriage has an estimated incidence of 30%, whilst clini..