Sensitivity to the environment: Risk and resilience for adolescent depression
Grant number: 1007716 | Funding period: 2012 - 2015
Depression is among the leading causes of disability and disease burden throughout the world. Little is known about how biological and environmental factors interact to cause adolescent depression; even less is known about what factors might help to prevent it. This project aims to investigate how the brain and the environment interact to predict risk and resilience for depression in adolescence. This research will ultimately help in the detection and treatment of adolescent depression.
Related publications (54)
Parental Physical Illnesses and Their Association with Subsequent Externalizing and Internalizing Symptoms in Children
Lotta Kinnunen, Tanja Nordstrom, Mika Niemela, Sami Rasanen, Sarah Whittle, Jouko Miettunen
Parental physical illnesses can be stressful for children. We estimated the prevalence of children who experience parental physica..
The long-term associations between parental behaviors, cognitive function and brain activation in adolescence
Orwa Dandash, Nicolas Cherbuin, Orli Schwartz, Nicholas B Allen, Sarah Whittle
Parenting behavior has a vital role in the development of the brain and cognitive abilities of offspring throughout childhood and ..
Towards understanding neurocognitive mechanisms of parenting: Maternal behaviors and structural brain network organization in late childhood
Sally Richmond, Richard Beare, Katherine A Johnson, Nicholas B Allen, Marc L Seal, Sarah Whittle
A substantial body of knowledge suggests that exposure to adverse family environments - including violence and neglect - influence..
Exploratory Factor Analysis of Observational Parent-Child Interaction Data
Sally Richmond, Orli Schwartz, Katherine A Johnson, Marc L Seal, Katherine Bray, Camille Deane, Lisa B Sheeber, Nicholas B Allen, Sarah Whittle
The majority of studies using observational coding systems for family interaction data derive scales describing family members' be..
Pubertal hormones predict sex-specific trajectories of pituitary gland volume during the transition from childhood to adolescence
Sarah Whittle, Marjolein Barendse, Elena Pozzi, Nandita Vijayakumar, Julian G Simmons
Pituitary gland volume (PGV) increases during childhood and adolescence in a sex-specific manner, and previous research suggests t..
Cortical surface morphology in long-term cannabis users: A multi-site MRI study
Yann Chye, Chao Suoa, Valentina Lorenzetti, Albert Batalla, Janna Cousijn, Anna E Goudriaan, Rocio Martin-Santos, Sarah Whittle, Nadia Solowij, Murat Yucel
Cannabis exerts its psychoactive effect through cannabinoid receptors that are widely distributed across the cortical surface of t..
Structural covariance networks in children and their associations with maternal behaviors
Sally Richmond, Richard Beare, Katherine A Johnson, Nicholas B Allen, Marc L Seal, Sarah Whittle
There is a substantial body of research documenting the influence of early adverse experience on brain development. In contrast, r..
Interaction between hypothalamic-pituitary-adrenal axis genetic variation and maternal behavior in the prediction of amygdala connectivity in children
Elena Pozzi, Chad A Bousman, Julian G Simmons, Nandita Vijayakumar, Orli Schwartz, Marc Seal, Marie BH Yap, Nicholas B Allen, Sarah L Whittle
High levels of negative, and low levels of positive parenting behaviors can increase the risk of internalizing symptoms in childre..
Sometimes It's Good to be Short: The Serotonin Transporter Gene, Positive Parenting, and Adolescent Depression
Keriann Little, Craig A Olsson, Sarah Whittle, Jacqui A Macdonald, Lisa B Sheeber, George J Youssef, Julian G Simmons, Ann V Sanson, Debra L Foley, Nicholas B Allen
In threatening environments, the short (S) allele of 5-HTTLPR is proposed to augment risk for depression. However, it is unknown w..
Childhood maltreatment, pituitary volume and adolescent hypothalamic-pituitary-adrenal axis -Evidence for a maltreatment-related attenuation
Michael Kaess, Sarah Whittle, Laurie O'Brien-Simpson, Nicholas B Allen, Julian G Simmons
BACKGROUND: Alterations of the development of the hypothalamic-pituitary-adrenal axis (HPAA) have been suggested to be related to ..
An fMRI study of theory of mind in individuals with first episode psychosis
Cali F Bartholomeusz, Eleni P Ganella, Sarah Whittle, Kelly Allott, Andrew Thompson, Ahmad Abu-Akerl, Henrik Walter, Patrick McGorry, Eoin Killackey, Christos Pantelis, Stephen J Wood
Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the ..
Amygdala volume mediates the relationship between externalizing symptoms and daily smoking in adolescence: A prospective study
Ali Cheetham, Nicholas B Allen, Sarah Whittle, Julian Simmons, Murat Yucel, Dan Lubman
The current study examined amygdala and orbitofrontal cortex (OFC) volumes as mediators of the relationship between externalizing ..
Duration of Breastfeeding and Subsequent Adolescent Obesity: Effects of Maternal Behavior and Socioeconomic Status
Michelle L Byrne, Orli S Schwartz, Julian G Simmons, Lisa Sheeber, Sarah Whittle, Nicholas B Allen
PURPOSE: Previous research has shown that longer duration of breastfeeding is associated with less risk of obesity in childhood an..
Cortico-amygdalar maturational coupling is associated with depressive symptom trajectories during adolescence
Nandita Vijayakumar, Nicholas B Allen, Meg Dennison, Michelle L Byrne, Julian G Simmons, Sarah Whittle
BACKGROUND: Adolescence is characterized by increasing prevalence of depressive symptomatology, along with significant structural ..
Role of Positive Parenting in the Association Between Neighborhood Social Disadvantage and Brain Development Across Adolescence
Sarah Whittle, Nandita Vijayakumar, Julian G Simmons, Meg Dennison, Orli Schwartz, Christos Pantelis, Lisa Sheeber, Michelle L Byrne, Nicholas B Allen
Importance: The negative effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence suggesti..
Brain Structural Signatures of Adolescent Depressive Symptom Trajectories: A Longitudinal Magnetic Resonance Imaging Study
Lianne Schmaal, Murat Yucel, Rachel Ellis, Nandita Vijayakumar, Julian G Simmons, Nicholas B Allen, Sarah Whittle
OBJECTIVE: Most evidence for structural brain abnormalities associated with adolescent depression is based on cross-sectional stud..
Physiological correlates of emotional reactivity and regulation in early adolescents
Melissa D Latham, Nina Cook, Julian G Simmons, Michelle L Byrne, Jonathan WL Kettle, Orli Schwartz, Nandita Vijayakumar, Sarah Whittle, Nicholas B Allen
Few studies have examined physiological correlates of emotional reactivity and regulation in adolescents, despite the occurrence i..
A systematic review of adrenarche as a sensitive period in neurobiological development and mental health
Michelle L Byrne, Sarah Whittle, Nandita Vijayakumar, Meg Dennison, Julian G Simmons, Nicholas B Allen
Substantial hormonal and neurobiological changes occur during puberty, and are widely argued to render this period of life a sensi..
Brain connectivity networks and longitudinal trajectories of depression symptoms in adolescence
Rachel Ellis, Marc L Seal, Christopher Adamson, Richard Beare, Julian G Simmons, Sarah Whittle, Nicholas B Allen
High levels of depression during adolescence may contribute to the risk for future depression later in life. This study examined t..
Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence
Sarah Whittle, Julian G Simmons, Sylke Hendriksma, Nandita Vijayakumar, Michelle L Byrne, Meg Dennison, Nicholas B Allen
INTRODUCTION: It is well established that childhood maltreatment has a detrimental impact on the brain, particularly the hippocamp..
Development of brain networks and relevance of environmental and genetic factors: A systematic review
Sally Richmond, Katherine A Johnson, Marc L Seal, Nicholas B Allen, Sarah Whittle
This study conducted a systematic review to synthesize findings on the development of functional and structural brain networks fro..
Feelings of shame, embarrassment and guilt and their neural correlates: A systematic review
Coralie Bastin, Ben J Harrison, Christopher G Davey, Jorge Moll, Sarah Whittle
This systematic review aimed to provide a comprehensive summary of the current literature on the neurobiological underpinnings of ..
Olfactory sulcus morphology in patients with current and past major depression
Tsutomu Takahashi, Yumiko Nishikawa, Murat Yucel, Sarah Whittle, Valentina Lorenzetti, Mark Walterfang, Daiki Sasabayashi, Michio Suzuki, Christos Pantelis, Nicholas B Allen
Olfactory deficits have been reported in major depressive disorder (MDD). However, it remains largely unknown whether MDD is assoc..
White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids
Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger
BACKGROUND: Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain ..
Trajectories of adolescent conduct problems in relation to cortical thickness development: a longitudinal MRI study
S Oostermeijer, S Whittle, C Suo, NB Allen, JG Simmons, N Vijayakumar, PM van de Ven, LMC Jansen, M Yucel, A Popma
Multiple cross-sectional imaging studies have identified structural abnormalities in prefrontal, temporal and limbic regions relat..
Neurodevelopmental correlates of proneness to guilt and shame in adolescence and early adulthood
Sarah Whittle, Kirra Liu, Coralie Bastin, Ben J Harrison, Christopher G Davey
Investigating how brain development during adolescence and early adulthood underlies guilt- and shame-proneness may be important f..
Associations between dehydroepiandrosterone (DHEA) levels, pituitary volume, and social anxiety in children
Cynthia R Murray, Julian G Simmons, Nicholas B Allen, Michelle L Byrne, Lisa K Mundy, Marc L Seal, George C Patton, Craig A Olsson, Sarah Whittle
Early timing of adrenarche, associated with relatively high levels of dehydroepiandrosterone (DHEA) and its sulphate (DHEA-S) in c..
Observed Measures of Negative Parenting Predict Brain Development during Adolescence
Sarah Whittle, Nandita Vijayakumar, Meg Dennison, Orli Schwartz, Julian G Simmons, Lisa Sheeber, Nicholas B Allen
Limited attention has been directed toward the influence of non-abusive parenting behaviour on brain structure in adolescents. It ..
Linking the Serotonin Transporter Gene, Family Environments, Hippocampal Volume and Depression Onset: A Prospective Imaging Gene X Environment Analysis
Keriann Little, Craig A Olsson, George J Youssef, Sarah Whittle, Julian G Simmons, Murat Yuecel, Lisa B Sheeber, Debra L Foley, Nicholas B Allen
A single imaging gene-environment (IGxE) framework that is able to simultaneously model genetic, neurobiological, and environmenta..
Associations between early adrenarche, affective brain function and mental health in children
Sarah Whittle, Julian G Simmons, Michelle L Byrne, Cherie Strikwerda-Brown, Rebecca Kerestes, Marc L Seal, Craig A Olsson, Paul Dudgeon, Lisa K Mundy, George C Patton, Nicholas B Allen
Early timing of adrenarche, associated with relatively high levels of Dehydroepiandrosterone (DHEA) in children, has been associat..
Dispositional mindfulness is predicted by structural development of the insula during late adolescence
S Friedel, SL Whittle, N Vijayakumar, JG Simmons, ML Byrne, OS Schwartz, NB Allen
Adolescence is a critical period of development, in which the increasing social and cognitive demands of independence need to be m..
Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression
CG Davey, S Whittle, BJ Harrison, JG Simmons, ML Byrne, OS Schwartz, NB Allen
BACKGROUND: The amygdala and subgenual anterior cingulate cortex (sACC) are key brain regions for the generation of negative affec..
The influence of sex, temperament, risk-taking and mental health on the emergence of gambling: a longitudinal study of young people
Murat Yuecel, Sarah Whittle, George J Youssef, Himani Kashyap, Julian G Simmons, Orli Schwartz, Dan I Lubman, Nicholas B Allen
There are a host of complex and interlinked psychological, social and biological factors involved in the development of problem ga..
Early life stress alters pituitary growth during adolescence-A longitudinal study
Despina E Ganella, Nicholas B Allen, Julian G Simmons, Orli Schwartz, Jee Hyun Kim, Lisa Sheeber, Sarah Whittle
The pituitary gland is integral in mediating the stress-response via its role in hypothalamic-pituitary-adrenal (HPA) axis functio..
Trait positive affect is associated with hippocampal volume and change in caudate volume across adolescence
Meg Dennison, Sarah Whittle, Murat Yuecel, Michelle L Byrne, Orli Schwartz, Julian G Simmons, Nicholas B Allen
Trait positive affect (PA) in childhood confers both risk and resilience to psychological and behavioral difficulties in adolescen..
Reduced frontal white matter volume in children with early onset of adrenarche
Paul Klauser, Sarah Whittle, Julian G Simmons, Michelle L Byrne, Lisa K Mundy, George C Patton, Alex Fornito, Nicholas B Allen
While there is growing evidence that puberty affects brain development, very little is known about the structural brain changes as..
Relationship between amygdala volume and emotion recognition in adolescents at ultra-high risk for psychosis
Cali F Bartholomeusz, Sarah L Whittle, Eleanor Pilioussis, Kelly Allott, Simon Rice, Miriam R Schaefer, Christos Pantelis, G Paul Amminger
Amygdala volume has been proposed as a neural risk biomarker for psychotic illness, but findings in the ultra-high risk for psycho..
Thinning of the lateral prefrontal cortex during adolescence predicts emotion regulation in females
Nandita Vijayakumar, Sarah Whittle, Murat Yuecel, Meg Dennison, Julian Simmons, Nicholas B Allen
Adolescence is a crucial period for the development of adaptive emotion regulation strategies. Despite the fact that structural ma..
Large-Scale Brain Network Dynamics Supporting Adolescent Cognitive Control
Dominic B Dwyer, Ben J Harrison, Murat Yuecel, Sarah Whittle, Andrew Zalesky, Christos Pantelis, Nicholas B Allen, Alex Fornito
Adolescence is a time when the ability to engage cognitive control is linked to crucial life outcomes. Despite a historical focus ..
Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study
K Little, CA Olsson, S Whittle, GJ Youssef, ML Byrne, JG Simmons, M Yuecel, DL Foley, NB Allen
The extent to which brain structural abnormalities might serve as neurobiological endophenotypes that mediate the link between the..
Development of temperamental effortful control mediates the relationship between maturation of the prefrontal cortex and psychopathology during adolescence: A 4-year longitudinal study
Nandita Vijayakumar, Sarah Whittle, Meg Dennison, Murat Yuecel, Julian Simmons, Nicholas B Allen
This study investigated the relationship between the development of effortful control (EC), a temperamental measure of self-regula..
Structural Brain Development and Depression Onset During Adolescence: A Prospective Longitudinal Study
Sarah Whittle, Renee Lichter, Meg Dennison, Nandita Vijayakumar, Orli Schwartz, Michelle L Byrne, Julian G Simmons, Murat Yuecel, Christos Pantelis, Patrick McGorry, Nicholas B Allen
OBJECTIVE: The authors sought to investigate whether the structural development of limbic, striatal, and prefrontal regions that a..
Study protocol: Imaging brain development in the Childhood to Adolescence Transition Study (iCATS)
Julian G Simmons, Sarah L Whittle, George C Patton, Paul Dudgeon, Craig Olsson, Michelle L Byrne, Lisa K Mundy, Marc L Seal, Nicholas B Allen
BACKGROUND: Puberty is a critical developmental phase in physical, reproductive and socio-emotional maturation that is associated ..
Positive parenting predicts the development of adolescent brain structure: A longitudinal study
Sarah Whittle, Julian G Simmons, Meg Dennison, Nandita Vijayakumar, Orli Schwartz, Marie BH Yap, Lisa Sheeber, Nicholas B Allen
Little work has been conducted that examines the effects of positive environmental experiences on brain development to date. The a..
Sulcogyral pattern and sulcal count of the orbitofrontal cortex in individuals at ultra high risk for psychosis
Suzie Lavoie, Cali F Bartholomeuz, Barnaby Nelson, Ashleigh Lin, Patrick D McGorry, Dennis Velakoulis, Sarah L Whittle, Alison R Yung, Christos Pantelis, Stephen J Wood
Three types of orbitofrontal cortex (OFC) sulcogyral patterns have been identified in the general population. The distribution of ..
Volumetric differences in the anterior cingulate cortex prospectively predict alcohol-related problems in adolescence
Ali Cheetham, Nicholas B Allen, Sarah Whittle, Julian Simmons, Murat Yuecel, Dan I Lubman
RATIONALE: Individual differences in brain structure and function are suggested to exist prior to the onset of alcohol abuse. Cros..
Sex-specific prediction of hypothalamic-pituitary-adrenal axis activity by pituitary volume during adolescence: A longitudinal study from 12 to 17 years of age
Michael Kaess, Julian G Simmons, Sarah Whittle, Martina Jovev, Andrew M Chanen, Murat Yuecel, Christos Pantelis, Nicholas B Allen
OBJECTIVE: To investigate the longitudinal relationship between pituitary gland volume (PGV) and parameters of hypothalamic-pituit..
Childhood Maltreatment and Psychopathology Affect Brain Development During Adolescence
Sarah Whittle, Meg Dennison, Nandita Vijayakumar, Julian G Simmons, Murat Yuecel, Dan I Lubman, Christos Pantelis, Nicholas B Allen
OBJECTIVE: The hippocampus and amygdala have received much attention with regard to the deleterious effects of childhood maltreatm..
Mapping subcortical brain maturation during adolescence: evidence of hemisphere- and sex-specific longitudinal changes
Meg Dennison, Sarah Whittle, Murat Yuecel, Nandita Vijayakumar, Alexandria Kline, Julian Simmons, Nicholas B Allen
Early to mid-adolescence is an important developmental period for subcortical brain maturation, but longitudinal studies of these ..
Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis
Cali F Bartholomeusz, Sarah L Whittle, Alice Montague, Brendan Ansell, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood
Three types of OFC sulcogyral patterns have been identified in the general population. The distribution of these three types has b..
Alteration to hippocampal shape in cannabis users with and without schizophrenia
Nadia Solowij, Mark Walterfang, Dan I Lubman, Sarah Whittle, Valentina Lorenzetti, Martin Styner, Dennis Velakoulis, Christos Pantelis, Murat Yuecel
Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users...