DEVELOPMENT OF NOVEL MEDICAL THERAPIES TO CURE ECTOPIC PREGNANCIES
Grant number: 606611 | Funding period: 2011 - 2013
Ectopic pregnancies are conceptions implanting outside the womb, mainly the fallopian tube. They are pathological, and can erode straight through the tube into large blood vessels causing fatal bleeding and death. We plan to assess three medication based approaches to treat this condition that would avoid surgery entirely. If we succeed, and subsequently translate one or more of these treatments to the clinic, it would revolutionise management of this serious gynaecological emergency.
Related publications (6)
Combination gefitinib and methotrexate treatment for non-tubal ectopic pregnancies: a case series
AW Horne, MM Skubisz, S Tong, WC Duncan, P Neil, EM Wallace, TG Johns
Non-tubal ectopic pregnancies are a rare subgroup of ectopic pregnancies implanted at sites other than the Fallopian tube. Mortali..
Combination Gefitinib and Methotrexate Compared With Methotrexate Alone to Treat Ectopic Pregnancy
Monika M Skubisz, Andrew W Horne, Terrance G Johns, Ulrika W Nilsson, W Colin Duncan, Euan M Wallace, Hilary OD Critchley, Stephen Tong
OBJECTIVE: To determine the safety, tolerability, and efficacy of combination gefitinib and methotrexate to treat ectopic pregnanc..
Effects of Gefitinib, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth
Ulrika W Nilsson, Terrance G Johns, Tania Wilmann, Tu'uhevaha Kaitu'u-Lino, Clare Whitehead, Eva Dimitriadis, Ellen Menkhorst, Burcu Saglam, Yane Gao, Sameer A Greenall, Andrew W Horne, Stephen Tong
OBJECTIVE: Placenta has the highest expression of epidermal growth factor (EGF) receptor of all tissues, a cell signaling pathway ..
Maternal Serum Macrophage Inhibitory Cytokine-1 as a Biomarker for Ectopic Pregnancy in Women with a Pregnancy of Unknown Location
Monika M Skubisz, Jeremy K Brown, Stephen Tong, Tu'uhevaha Kaitu'u-Lino, Andrew W Horne
BACKGROUND: Ectopic pregnancy (EP) occurs in 1-2% of pregnancies, but is over-represented as a leading cause of maternal death in ..
Targeted Nanoparticle Delivery of Doxorubicin Into Placental Tissues to Treat Ectopic Pregnancies
Tu'uhevaha J Kaitu'u-Lino, Scott Pattison, Louie Ye, Laura Tuohey, Pavel Sluka, Jennifer MacDiarmid, Himanshu Brahmbhatt, Terrence Johns, Andrew W Horne, Jeremy Brown, Stephen Tong
Abnormal trophoblast growth can cause life-threatening disorders such as ectopic pregnancy, choriocarcinoma, and placenta accreta...
Evaluation of ADAM-12 as a Diagnostic Biomarker of Ectopic Pregnancy in Women with a Pregnancy of Unknown Location
Andrew W Horne, Jeremy K Brown, Stephen Tong, Tu'uhevaha Kaitu'u-Lino
BACKGROUND: Ectopic pregnancy (EP) remains the most life-threatening acute condition in modern gynaecology. It remains difficult t..