Development of Novel Medical Therapies to Cure Ectopic Pregnancies

Grant number: 606611 | Funding period: 2011 - 2013

Completed

Abstract

Ectopic pregnancies are conceptions implanting outside the womb, mainly the fallopian tube. They are pathological, and can erode straight through the tube into large blood vessels causing fatal bleeding and death. We plan to assess three medication based approaches to treat this condition that would avoid surgery entirely. If we succeed, and subsequently translate one or more of these treatments to the clinic, it would revolutionise management of this serious gynaecological emergency.

Related publications (6)

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Combination gefitinib and methotrexate treatment for non-tubal ectopic pregnancies: A case series

AW Horne, MM Skubisz, S Tong, WC Duncan, P Neil, EM Wallace, TG Johns

2014-01-01

Non-tubal ectopic pregnancies are a rare subgroup of ectopic pregnancies implanted at sites other than the Fallopian tube. Mortali..

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Combination gefitinib and methotrexate compared with methotrexate alone to treat ectopic pregnancy

MM Skubisz, AW Horne, TG Johns, UW Nilsson, WC Duncan, EM Wallace, HOD Critchley, S Tong

2013-10-01

OBJECTIVE: To determine the safety, tolerability, and efficacy of combination gefitinib and methotrexate to treat ectopic pregnanc..

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Maternal Serum Macrophage Inhibitory Cytokine-1 as a Biomarker for Ectopic Pregnancy in Women with a Pregnancy of Unknown Location

MM Skubisz, JK Brown, S Tong, T Kaitu'u-Lino, AW Horne

2013-06-18

Background:Ectopic pregnancy (EP) occurs in 1-2% of pregnancies, but is over-represented as a leading cause of maternal death in e..

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Targeted nanoparticle delivery of doxorubicin into placental tissues to treat ectopic pregnancies

TJ Kaitu'u-Lino, S Pattison, L Ye, L Tuohey, P Sluka, J MacDiarmid, H Brahmbhatt, T Johns, AW Horne, J Brown, S Tong

2013-02-01

Abnormal trophoblast growth can cause life-threatening disorders such as ectopic pregnancy, choriocarcinoma, and placenta accreta...

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Effects of gefitinib, an epidermal growth factor receptor inhibitor, on human placental cell growth

UW Nilsson, TG Johns, T Wilmann, T Kaitu'u-Lino, C Whitehead, E Dimitriadis, E Menkhorst, B Saglam, Y Gao, SA Greenall, AW Horne, S Tong

2013-01-01

Placenta has the highest expression of epidermal growth factor (EGF) receptor of all tissues, a cell signaling pathway promoting s..

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Evaluation of ADAM-12 as a diagnostic biomarker of ectopic pregnancy in women with a pregnancy of unknown location

AW Horne, JK Brown, S Tong, T Kaitu'u-Lino

2012-08-21

Background: Ectopic pregnancy (EP) remains the most life-threatening acute condition in modern gynaecology. It remains difficult t..

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