Understanding What Causes Epilepsy

Abstract

About 100 000 people suffer from epilepsy in Australia with about one third poorly controlled with current anti-epileptic drugs. It is important to continue to develop novel modes of treatment for this debilitating disease. This project investigates an ion channel, known as HCN that is thought to be involved in making a brain epileptic. Understanding how changes in HCN channels make nerve cells and nerve networks more excitable will help us develop better strategies for designing drugs.

Related publications (2)

Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsy

A Marie Phillips, Taehwan Kim, Ernesto Vargas, Steven Petrou, Christopher A Reid

2014-04-01

SPIKE-AND-WAVE DISCHARGE MEDIATED REDUCTION IN HIPPOCAMPAL HCN1 CHANNEL FUNCTION ASSOCIATES WITH LEARNING DEFICITS IN A GENETIC MOUSE MODEL OF EPILEPSY

AM Phillips, TH Kim, E Vargas, S Petrou, CA Reid

2013-06-01