Novel Anti-Ageing Peptides in the Vascular System

Grant number: LP110200543 | Funding period: 2012 - 2015

Completed

Abstract

The project will substantially improve basic understanding of the ageing process in blood vessels and provide scientific evidence to understand what preventative health care measures might work and why. It will also produce highly skilled and practically trained graduates, ready to contribute to the health industry.

Related publications (4)

Relaxin elicits renoprotective actions accompanied by increasing bile acid levels in streptozotocin-induced diabetic mice

CH Leo, JLM Ou, ES Ong, CX Qin, RH Ritchie, LJ Parry, HH Ng

2023-06-01

Background: The peptide hormone relaxin has potent anti-fibrotic and anti-inflammatory properties in various organs, including the..

Relaxin as a therapeutic target for the cardiovascular complications of diabetes

HH Ng, CH Leo, LJ Parry, RH Ritchie

2018-05-15

Cardiovascular complications are the major cause of mortality in patients with diabetes. This is closely associated with both macr..

Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes

HH Ng, CH Leo, D Prakoso, C Qin, RH Ritchie, LJ Parry

2017-01-09

Serelaxin prevents endothelial dysfunction in the mouse aorta ex vivo and inhibits apoptosis in cardiomyocytes under acute hypergl..

Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

M Jelinic, CH Leo, ED Post Uiterweer, SL Sandow, JH Gooi, ME Wlodek, KP Conrad, H Parkington, M Tare, LJ Parry

2014-01-01

Relaxin is a potent vasodilator of small resistance arteries and modifies arterial compliance in some systemic vascular beds, yet ..

University of Melbourne Researchers

Mary Wlodek