Novel anti-ageing peptides in the vascular system

Grant number: LP110200543 | Funding period: 2012 - 2015

Completed

Abstract

The project will substantially improve basic understanding of the ageing process in blood vessels and provide scientific evidence to understand what preventative health care measures might work and why. It will also produce highly skilled and practically trained graduates, ready to contribute to the health industry.

Related publications (5)

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Peptide hormone relaxin: from bench to bedside

Maria Jelinic, Sarah A Marshall, Dennis Stewart, Elaine Unemori, Laura J Parry, Chen Huei Leo

2018-06-01

The peptide hormone relaxin has numerous roles both within and independent of pregnancy and is often thought of as a "pleiotropic ..

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Short-term (48hours) intravenous serelaxin infusion has no effect on myogenic tone or vascular remodeling in rat mesenteric arteries

Maria Jelinic, Chen Huei Leo, Sarah A Marshall, Sevvandi N Senadheera, Laura J Parry, Marianne Tare

2017-08-01

BACKGROUND: Short-term IV sRLX (recombinant human relaxin-2) infusion enhances endothelium-dependent relaxation in mesenteric arte..

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Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes

Hooi Hooi Ng, Chen Huei Leo, Darnel Prakoso, Chengxue Qin, Rebecca H Ritchie, Laura J Parry

2017-01-09

Serelaxin prevents endothelial dysfunction in the mouse aorta ex vivo and inhibits apoptosis in cardiomyocytes under acute hypergl..

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A Vasoactive Role for Endogenous Relaxin in Mesenteric Arteries of Male Mice

Chen Huei Leo, Maria Jelinic, Jon H Gooi, Marianne Tare, Laura J Parry

2014-09-22

The peptide hormone relaxin has striking effects on the vascular system. Specifically, endogenous relaxin treatment reduces myogen..

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Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin- mediated relaxation after in vivo serelaxin treatment

Maria Jelinic, Chen-Huei Leo, Emiel D Post Uiterweer, Shaun L Sandow, Jonathan H Gooi, Mary E Wlodek, Kirk P Conrad, Helena Parkington, Marianne Tare, Laura J Parry

2014-01-01

Relaxin is a potent vasodilator of small resistance arteries and modifies arterial compliance in some systemic vascular beds, yet ..

University of Melbourne Researchers