PROBING SEXUAL TRANSFORMATION OF THE HUMAN MALARIA PARASITE,PLASMODIUM FALCIPARUM,USING NOVEL IMAGING MODALITIES
Grant number: DP110100624 | Funding period: 2011 - 2015
Malaria parasites adopt a characteristic banana shape prior to sexual recombination; without this shape change disease transmission via mosquitoes cannot occur. This project will use advanced imaging technologies to study sexual recombination of malaria with a view to preventing the millions of deaths due to malaria each year.
Related publications (7)
Role of Plasmodium falciparum Protein GEXPO7 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking
Emma McHugh, Olivia MS Carmo, Adam Blanch, Oliver Looker, Boyin Liu, Snigdha Tiash, Dean Andrew, Steven Batinovic, Andy JY Low, Hyun-Jung Cho, Paul McMillan, Leann Tilley, Matthew WA Dixon
The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to..
The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly
Oliver Looker, Adam J Blanch, Boyin Liu, Juan Nunez-Iglesias, Paul J McMillan, Leann Tilley, Matthew WA Dixon
Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood vessel walls by assembling a multi-protein com..
Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development
Molly Parkyn Schneider, Boyin Liu, Philipp Glock, Annika Suttie, Emma McHugh, Dean Andrew, Steven Batinovic, Nicholas Williamson, Eric Hanssen, Paul McMillan, Marion Hliscs, Leann Tilley, Matthew WA Dixon
Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the hu..
A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability
Fabio L da Silva, Matthew WA Dixon, Colin M Stack, Franka Teuscher, Elena Taran, Malcolm K Jones, Erica Lovas, Leann Tilley, Christopher L Brown, Katharine R Trenholme, John P Dalton, Donald L Gardiner, Tina S Skinner-Adams
Infection with the apicomplexan parasite Plasmodium falciparum is a major cause of morbidity and mortality worldwide. One of the s..
Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains
Tuo Yang, Stanley C Xie, Pengxing Cao, Carlo Giannangelo, James McCaw, Darren J Creek, Susan A Charman, Nectarios Klonis, Leann Tilley
Fully synthetic endoperoxide antimalarials, namely, OZ277 (RBx11160; also known as arterolane) and OZ439 (artefenomel), have been ..
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnaedig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley
Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that r..
Organization and function of an actin cytoskeleton in Plasmodium falciparum gametocytes
Marion Hliscs, Coralie Millet, Matthew W Dixon, Inga Siden-Kiamos, Paul McMillan, Leann Tilley
In preparation for transmission to its mosquito vector, Plasmodium falciparum, the most virulent of the human malaria parasites, a..