Rna Interference And Retigabine Therapy Protect Against Hereditary Hearing Loss

Grant number: 546493 | Funding period: 2011 - 2014

Completed

Abstract

The preservation of hearing function is central to the treatment of individuals who are genetically predisposed to hearing loss. At present only synthetic hearing aids and cochlear implants can provide functional improvement, albeit sub-optimal. The studies described here will seek to prevent hearing loss by reducing the damaging effects of defective genes. Gene therapies that reduce the effect of these defective genes and a drug that enhances the activity of functional genes will be developed.