MEASURING RNA IN MATERNAL BLOOD TO MONITOR THE WELLBEING OF GROWTH-RESTRICTED FETUSES
Grant number: 1028521 | Funding period: 2012 - 2015
Severely growth restricted fetuses are at peril of stillbirth from low oxygenation. While ultrasound monitoring improves outcomes, babies are still lost. Better ways to monitor the health the unborn baby are needed. We have recently discovered fetuses’ starved of oxygen leak RNA into mother's blood. Thus, measuring RNA molecules in blood could be used to assess fetal health. We will examine whether measuring mRNA in maternal blood could be used to monitor wellbeing of growth-restricted fetuses.
Related publications (9)
Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth
Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong
Background Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted..
Severe placental insufficiency, acidemia and imminent stillbirth are associated with changes in circulating levels of mRNA coding NR4A2, RCBTB2 and EMP1
Stephen Tong, Clare Whitehead, Susan Walker, Gordon Lavinia, Jo Said, Katie Groom, Scott Petersen, Sean Seeho, Amanda Henry, Stefan Kane, Natalie Hannan, Owen Stock
Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation
Clare L Whitehead, Helen McNamara, Susan P Walker, Maria Alexiadis, Peter J Fuller, Daniel K Vickers, Natalie J Hannan, Roxanne Hastie, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong
BACKGROUND: Late-onset fetal growth restriction (FGR) is often undetected prior to birth, which puts the fetus at increased risk o..
Quantifying circulating hypoxia-induced RNA transcripts in maternal blood to determine in utero fetal hypoxic status
Clare Whitehead, Wan Tinn Teh, Susan P Walker, Cheryl Leung, Sonali Mendis, Luke Larmour, Stephen Tong
BACKGROUND: Hypoxia in utero can lead to stillbirth and severe perinatal injury. While current prenatal tests can identify fetuses..
Circulating MicroRNAs in Maternal Blood as Potential Biomarkers for Fetal Hypoxia In-Utero
Clare L Whitehead, Wan Tinn Teh, Susan P Walker, Cheryl Leung, Luke Larmour, Stephen Tong
Stillbirth affects 1 in 200 pregnancies and commonly arises due to a lack of oxygen supply to the fetus. Current tests to detect f..
Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia
CL Whitehead, SP Walker, M Lappas, S Tong
OBJECTIVE: To determine whether the intrinsic apoptosis pathway is differentially expressed in placenta and maternal blood in seve..
Quantifying mRNA coding growth genes in the maternal circulation to detect fetal growth restriction
Clare L Whitehead, Susan P Walker, Sonali Mendis, Martha Lappas, Stephen Tong
OBJECTIVE: To examine whether mRNA circulating in maternal blood coding genes regulating fetal growth are differentially expressed..
Placental Specific mRNA in the Maternal Circulation Are Globally Dysregulated in Pregnancies Complicated by Fetal Growth Restriction
Clare L Whitehead, Susan P Walker, Louie Ye, Sonali Mendis, Tu'uhevaha J Kaitu'u-Lino, Martha Lappas, Stephen Tong
CONTEXT: Fetal growth restriction (FGR) is a leading cause of perinatal mortality, yet no reliable screening test exists. Placenta..