Pericytes in cancer progression
Grant number: 1025874 | Funding period: 2012 - 2014
It is well accepted that the cells in the local environment of cancers can help to promote the growth and spread of tumour cells. We have shown that a cell type known as the pericyte previously thought to be involved in controlling tumour expansion by affecting new blood vessel formation, may directly influence tumour growth, a notion that will be tested in human skin and ovarian cancer models. We will also test if pericyte markers can predict those cancer patients at greater risk of relapse.
Related publications (2)
Pericytes Promote Malignant Ovarian Cancer Progression in Mice and Predict Poor Prognosis in Serous Ovarian Cancer Patients
Devbarna Sinha, Lynn Chong, Joshy George, Holger Schlueter, Susann Moenchgesang, Stuart Mills, Jason Li, Christopher Parish, David Bowtell, Pritinder Kaur
PURPOSE: The aim of this study was to investigate the role of pericytes in regulating malignant ovarian cancer progression. EXPERI..
The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis
Helen B Pearson, Edwina McGlinn, Toby J Phesse, Holger Schlueter, Anuratha Srikumar, Nathan J Goedde, Christina B Woelwer, Andrew Ryan, Wayne A Phillips, Matthias Ernst, Pritinder Kaur, Patrick Humbert
BACKGROUND: The establishment and maintenance of polarity is vital for embryonic development and loss of polarity is a frequent ch..