Altered brain anatomy in genetic epilepsy
Grant number: 1030016 | Funding period: 2012 - 2015
Genetic generalized epilepsy (GGE) is the most common form of epilepsy, but our understanding of the pathogenesis, in particular anatomical effects of genetic mutations, is incomplete. This project represents the first quantitative study of anatomical changes caused by a human GGE mutation. Pilot data show that the fundamental wiring of the cortex is different in GGE brains with obvious implications for epileptogenesis. This study is expected to inspire improved treatment and diagnosis.
Related publications (3)
Sodium Channel beta 1 Subunit Localizes to Axon Initial Segments of Excitatory and Inhibitory Neurons and Shows Regional Heterogeneity in Mouse Brain
Verena C Wimmer, Rosemary C Harty, Kay L Richards, A Marie Phillips, Haruko Miyazaki, Nobuyuki Nukina, Steven Petrou
The β1 subunit of voltage-gated sodium channels, Nav β1, plays multiple roles in neurons spanning electrophysiological modulation ..
Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy
Rosemary C Harty, Tae Hwan Kim, Evan A Thomas, Lisa Cardamone, Nigel C Jones, Steven Petrou, Verena C Wimmer
A novel form of neuronal plasticity, occurring at the axon initial segment (AIS), has recently been described. Lengthening of the ..