A unique cause of photoreceptor death
Grant number: 1021918 | Funding period: 2012 - 2015
Abnormalities in cells at the back of the eye called photoreceptors are associated with at least 50% of all cases of blindness in this country.This project will examine a novel mechanism of photoreceptor death. In particular, whether abnormalties in support cells at the back of the eye cause photoreceptors to lose contact with their nutrient source and die.
Related publications (3)
The Role of Histamine in the Retina: Studies on the Hdc Knockout Mouse
Ursula Greferath, Kirstan A Vessey, Andrew I Jobling, Samuel A Mills, Bang V Bui, Zheng He, Nupur Nag, Hiroshi Ohtsu, Erica L Fletcher
The role of histamine in the retina is not well understood, despite it regulating a number of functions within the brain, includin..
Studying Age-Related Macular Degeneration Using Animal Models
Erica L Fletcher, Andrew I Jobling, Ursula Greferath, Samuel A Mills, Michelle Waugh, Tracy Ho, Robb U de Iongh, Joanna A Phipps, Kirstan A Vessey
Over the recent years, there have been tremendous advances in our understanding of the genetic and environmental factors associate..
Ccl2/Cx3cr1 Knockout Mice Have Inner Retinal Dysfunction but Are Not an Accelerated Model of AMD
Kirstan A Vessey, Ursula Greferath, Andrew I Jobling, Joanna A Phipps, Tracy Ho, Michelle Waugh, Erica L Fletcher
PURPOSE: The chemokine, Ccl2, and the fractalkine receptor, Cx3cr1, have both been implicated in the pathogenesis of age related m..