Diabetic Heart Disease - A New Therapeutic Approach for Heart Cell Protection

Grant number: 1027865 | Funding period: 2012 - 2015

Completed

Abstract

The heart is recognized as an important casualty organ in the progression of diabetes – both type 1 and type 2. We have new evidence that in diabetic and pre-diabetic hearts there is excess breakdown of heart cell structure in order to scavenge metabolic fuel, and that this scavenging can lead to heart cell death. Our goal is to identify ways in which the heart may be protected against this pathology and to identify new molecular targets for treatment of diabetic hearts.

Related publications (4)

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Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

KM Mellor, U Varma, P Koutsifeli, CL Curl, JV Janssens, LJ Daniels, GB Bernasochi, AJA Raaijmakers, M Annandale, X Li, SL James, DJ Taylor, K Raedschelders, KL Weeks, RJ Mills, RG Parton, X Hu, JR Bell, TJ O’Brien, R Katare

2025-11-01

Diabetic heart disease is highly prevalent and is associated with the early development of impaired diastolic relaxation. The mech..

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Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy

KM Mellor, U Varma, P Koutsifeli, LJ Daniels, VL Benson, M Annandale, X Li, Y Nursalim, JV Janssens, KL Weeks, KL Powell, TJ O'Brien, R Katare, RH Ritchie, JR Bell, RA Gottlieb, LMD Delbridge

2024-04-01

Diabetic heart disease morbidity and mortality is escalating. No specific therapeutics exist and mechanistic understanding of diab..

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Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

C Chandramouli, ME Reichelt, CL Curl, U Varma, LA Bienvenu, P Koutsifeli, AJA Raaijmakers, MJ De Blasio, CX Qin, AJ Jenkins, RH Ritchie, KM Mellor, LMD Delbridge

2018-12-01

Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascula..

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Myocardial autophagic energy stress responses—macroautophagy, mitophagy, and glycophagy

LMD Delbridge, KM Mellor, DJR Taylor, RA Gottlieb

2015-05-15

An understanding of the role of autophagic processes in the management of cardiac metabolic stress responses is advancing rapidly ..

University of Melbourne Researchers