Diabetic Heart Disease - A New Therapeutic Approach For Heart Cell Protection

Grant number: 1027865 | Funding period: 2012 - 2015

Completed

Abstract

The heart is recognized as an important casualty organ in the progression of diabetes – both type 1 and type 2. We have new evidence that in diabetic and pre-diabetic hearts there is excess breakdown of heart cell structure in order to scavenge metabolic fuel, and that this scavenging can lead to heart cell death. Our goal is to identify ways in which the heart may be protected against this pathology and to identify new molecular targets for treatment of diabetic hearts.