How the brain regulates reward
Grant number: 1021227 | Funding period: 2012 - 2014
Substance abuse is a significant social and economic burden upon Australian societies and on societies around the world. Treatment remains problematic due to the multi-layer nature of the disease, difficulties with treatment compliance and less than ideal treatment regimes. The present study aims to improve treatments for alcohol and drug abuse using pre-clinical models to identify and characterize a new brain system implicated in drug-seeking.
Related publications (8)
Nucleus incertus Orexin(2) receptors mediate alcohol seeking in rats
Hanna E Kastman, Anna Blasiak, Leigh Walker, Marcin Siwiec, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
Alcoholism is a chronic relapsing disorder and a major global health problem. Stress is a key precipitant of relapse in human alco..
Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats
Robyn Mary Brown, Andrezza K Kim, Shaun Yon-Seng Khoo, Jee Hyun Kim, Bianca Jupp, Andrew John Lawrence
Orexins (hypocretins) are hypothalamic neuropeptides that innervate the entire neuraxis, including the prelimbic cortex and ventra..
Relaxin-3 Receptor (RXFP3) Signalling Mediates Stress-Related Alcohol Preference in Mice
Andrew W Walker, Craig M Smith, Berenice E Chua, Elena V Krstew, Cary Zhang, Andrew L Gundlach, Andrew J Lawrence
Stressful life events are causally linked with alcohol use disorders (AUDs), providing support for a hypothesis that alcohol consu..
Knockdown of CRF1 Receptors in the Ventral Tegmental Area Attenuates Cue- and Acute Food Deprivation Stress-Induced Cocaine Seeking in Mice
Nicola A Chen, Bianca Jupp, Yehezkel Sztainberg, Maya Lebow, Robyn M Brown, Jee Hyun Kim, Alon Chen, Andrew J Lawrence
Corticotrophin-releasing factor (CRF) modulates the influence of stress on cocaine reward and reward seeking acting at multiple si..
The mGlu5 receptor regulates extinction of cocaine-driven behaviours
Michael K Bird, Peter Lohmann, Billy West, Robyn M Brown, Jeppe Kirchhoff, Clarke R Raymond, Andrew J Lawrence
BACKGROUND: There is extensive evidence implicating the metabotropic glutamate 5 (mGlu5) receptor in aspects of addiction-related ..
Relaxin-3/RXFP3 system regulates alcohol-seeking
Philip J Ryan, Hanna E Kastman, Elena V Krstew, K Johan Rosengren, Mohammed Akhter Hossain, Leonid Churilov, John D Wade, Andrew L Gundlach, Andrew J Lawrence
Relapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders. Usi..
Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats
Robyn Mary Brown, Shaun Yon-Seng Khoo, Andrew John Lawrence
Orexins are hypothalamic neuropeptides which bind to two G-protein-coupled receptors, orexin-1 (OX(1)R) and orexin-2 (OX(2)R) rece..