Towards Growing Large Pieces of Human Heart From Stem Cells

Grant number: 1024817 | Funding period: 2012 - 2015

Completed

Abstract

Stem cell therapies to repair heart muscle are experimental methods which promise future clinical treatments. Our tissue engineering chamber model provides a protective environment for implanted cells and generates contracting heart tissue. Towards clinical application we will scale up the tissue volume produced by: improving cell supply with new stem cell technologies, design chambers for bulk cell implantation, adopt a bionic approach to cell pacing and apply the model into larger animals.

Related publications (8)

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Harnessing the secretome of cardiac stem cells as therapy for ischemic heart disease

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Adult stem cells continue to promise opportunities to repair damaged cardiac tissue. However, precisely how adult stem cells accom..

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Electrical stimulation promotes cardiac differentiation of human induced pluripotent stem cells

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Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells

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Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering

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Enrichment of neonatal rat cardiomyocytes in primary culture facilitates long-term maintenance of contractility in vitro

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