New receptor protein targets for novel anti-cancer drugs
Grant number: 1023185 | Funding period: 2012 - 2014
Treatment of breast and other cancers is making incremental improvements, but premature death from this disease and its recurrence in some women after a long period of remission are not adequately treated by current drugs. New work has identified a target called FPR2 that could be used to guide the development of novel drugs. The current project seeks to validate the new drug target, before resource intensive efforts are made to find suitable drugs.
Related publications (7)
Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer
Cameron N Johnstone, Yan Tu, Shenna Langenbach, David Baloyan, Andrew D Pattison, Peter Lock, Kara L Britt, Brian D Lehmann, Traude H Beilharz, Matthias Ernst, Robin L Anderson, Alastair G Stewart
Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target th..
Glucocorticoid resistance of migration and gene expression in a daughter MDA-MB-231 breast tumour cell line selected for high metastatic potential
Ebony R Fietz, Christine R Keenan, Guillermo Lopez-Campos, Yan Tu, Cameron N Johnstone, Trudi Harris, Alastair G Stewart
Glucocorticoids are commonly used to prevent chemotherapy-induced nausea and vomiting despite a lack of understanding of their dir..
Annexin Al influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes
Yan Tu, Cameron N Johnstone, Alastair G Stewart
Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumu..
The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF
Michael Schuliga, Jade Jaffar, Trudi Harris, Darryl A Knight, Glen Westall, Alastair G Stewart
The role of urokinase plasminogen activator (uPA) in idiopathic pulmonary fibrosis (IPF) remains unclear. uPA-generated plasmin ha..
Resolvin D2 Supports MCF-7 Cell Proliferation via Activation of Estrogen Receptor
Nuha Al-Zaubai, Cameron N Johnstone, May May Leong, John Li, Mark Rizzacasa, Alastair G Stewart
Inflammation has been implicated in tumor initiation, angiogenesis, and metastasis, and linked to the development of more aggressi..
Total synthesis of the endogenous inflammation resolving lipid resolvin D2 using a common lynchpin
John Li, May May Leong, Alastair Stewart, Mark A Rizzacasa
The total synthesis of the endogenous inflammation resolving eicosanoid resolvin D2 (1) is described. The key steps involved a Wit..