New receptor protein targets for novel anti-cancer drugs

Grant number: 1023185 | Funding period: 2012 - 2014

Completed

Abstract

Treatment of breast and other cancers is making incremental improvements, but premature death from this disease and its recurrence in some women after a long period of remission are not adequately treated by current drugs. New work has identified a target called FPR2 that could be used to guide the development of novel drugs. The current project seeks to validate the new drug target, before resource intensive efforts are made to find suitable drugs.

Related publications (7)

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Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer

Cameron N Johnstone, Yan Tu, Shenna Langenbach, David Baloyan, Andrew D Pattison, Peter Lock, Kara L Britt, Brian D Lehmann, Traude H Beilharz, Matthias Ernst, Robin L Anderson, Alastair G Stewart

2021-03-01

Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target th..

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Glucocorticoid resistance of migration and gene expression in a daughter MDA-MB-231 breast tumour cell line selected for high metastatic potential

Ebony R Fietz, Christine R Keenan, Guillermo Lopez-Campos, Yan Tu, Cameron N Johnstone, Trudi Harris, Alastair G Stewart

2017-03-06

Glucocorticoids are commonly used to prevent chemotherapy-induced nausea and vomiting despite a lack of understanding of their dir..

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Annexin Al influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes

Yan Tu, Cameron N Johnstone, Alastair G Stewart

2017-03-01

Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumu..

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The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF

Michael Schuliga, Jade Jaffar, Trudi Harris, Darryl A Knight, Glen Westall, Alastair G Stewart

2017-01-31

The role of urokinase plasminogen activator (uPA) in idiopathic pulmonary fibrosis (IPF) remains unclear. uPA-generated plasmin ha..

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Inflammation: maladies, models, mechanisms and molecules

AG Stewart, PM Beart

2016-02-01

The continued focus of attention on the diversity of mechanisms underpinning inflammation has improved our understanding of the po..

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Resolvin D2 Supports MCF-7 Cell Proliferation via Activation of Estrogen Receptor

Nuha Al-Zaubai, Cameron N Johnstone, May May Leong, John Li, Mark Rizzacasa, Alastair G Stewart

2014-10-01

Inflammation has been implicated in tumor initiation, angiogenesis, and metastasis, and linked to the development of more aggressi..

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Total synthesis of the endogenous inflammation resolving lipid resolvin D2 using a common lynchpin

John Li, May May Leong, Alastair Stewart, Mark A Rizzacasa

2013-12-03

The total synthesis of the endogenous inflammation resolving eicosanoid resolvin D2 (1) is described. The key steps involved a Wit..