Can stem cells make functional connections?
Grant number: 1023372 | Funding period: 2012 - 2017
A major challenge in treating neurodegenerative conditions with stem cells, is to generate a population of donor cells which are capable of incorporating into the host nervous system and restoring function. This proposal will test the capacity of human stem cells to make functional connections in the auditory system, potentially enhancing hearing with a cochlear implant. These studies are critical in determining how stem cells may be used to promote functional regeneration of the damaged nervous system.
Related publications (4)
Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices
Tomoko Hyakumura, Stuart McDougall, Sue Finch, Karina Needham, Mirella Dottori, Bryony A Nayagam
Stem cells have been touted as a source of potential replacement neurons for inner ear degeneration for almost two decades now; ye..
Review: Using diffusion-weighted magnetic resonance imaging techniques to explore the microstructure and connectivity of subcortical white matter tracts in the human auditory system
Julien Zanin, Thijs Dhollander, Shawna Farquharson, Gary Rance, Alan Connelly, Bryony A Nayagam
Since its inception 30 years ago, diffusion-weighted magnetic resonance imaging (dMRI) has advanced to become a common component o..
Electrophysiological properties of neurosensory progenitors derived from human embryonic stem cells
Karina Needham, Tomoko Hyakumura, Niliksha Gunewardene, Mirella Dottori, Bryony A Nayagam
In severe cases of sensorineural hearing loss where the numbers of auditory neurons are significantly depleted, stem cell-derived ..