Methylation of DNA and colorectal cancer

Heritable methylation marks associated with prostate cancer risk.

James G Dowty, Chenglong Yu, Mahnaz Hosseinpour, Jihoon Eric Joo, Ee Ming Wong, Tu Nguyen-Dumont, Joseph Rosenbluh, Graham G Giles, Roger L Milne, Robert J MacInnis, Pierre-Antoine Dugué, Melissa C Southey

2023-01-28

DNA methylation marks that are inherited from parents to offspring are known to play a role in cancer risk and could explain part ..

Inflammation and Epigenetic Aging Are Largely Independent Markers of Biological Aging and Mortality

Lachlan Cribb, Allison M Hodge, Chenglong Yu, Sherly X Li, Dallas R English, Enes Makalic, Melissa C Southey, Roger L Milne, Graham G Giles, Pierre-Antoine Dugue

2022-08-04

Limited evidence exists on the link between inflammation and epigenetic aging. We aimed to (a) assess the cross-sectional and pros..

Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?

Chenglong Yu, Allison M Hodge, Ee Ming Wong, Jihoon E Joo, Enes Makalic, Daniel F Schmidt, Daniel D Buchanan, Gianluca Severi, John L Hopper, Dallas R English, Graham G Giles, Roger L Milne, Melissa C Southey, Pierre-Antoine Dugue

2022-06-17

Lifestyle-related phenotypes have been shown to be heritable and associated with DNA methylation. We aimed to investigate whether ..

Association of FOXO3 Blood DNA Methylation with Cancer Risk, Cancer Survival, and Mortality

Chenglong Yu, Allison M Hodge, Ee Ming Wong, Jihoon Eric Joo, Enes Makalic, Daniel Schmidt, Daniel D Buchanan, John L Hopper, Graham G Giles, Melissa C Southey, Pierre-Antoine Dugue

2021-12-01

Genetic variants in FOXO3 are associated with longevity. Here, we assessed whether blood DNA methylation at FOXO3 was associated w..

Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood

Pierre-antoine Dugue, Allison Hodge, Ee Ming Wong, Eric Joo, Chol-Hee Jung, John Hopper, Dallas English, Graham Giles, Roger Milne, Melissa Southey

2021-09-01

BACKGROUND: Prenatal exposure to maternal smoking is detrimental to child health but its association with risk of cancer has seldo..

Epigenetic Drift Association with Cancer Risk and Survival, and Modification by Sex

Chenglong Yu, Ee Ming Wong, Jihoon Eric Joo, Allison M Hodge, Enes Makalic, Daniel Schmidt, Daniel D Buchanan, Gianluca Severi, John L Hopper, Dallas R English, Graham G Giles, Melissa C Southey, Pierre-Antoine Dugue

2021-04-01

To investigate age- and sex-specific DNA methylation alterations related to cancer risk and survival, we used matched case-control..

VTRNA2-1: Genetic Variation, Heritable Methylation and Disease Association

Pierre-Antoine Dugue, Chenglong Yu, Timothy McKay, Ee Ming Wong, Jihoon Eric Joo, Helen Tsimiklis, Fleur Hammet, Maryam Mahmoodi, Derrick Theys, John L Hopper, Graham G Giles, Roger L Milne, Jason A Steen, James G Dowty, Tu Nguyen-Dumont, Melissa C Southey

2021-03-01

VTRNA2-1 is a metastable epiallele with accumulating evidence that methylation at this region is heritable, modifiable and associa..

Methylation scores for smoking, alcohol consumption, and body mass index and risk of seven types of cancer

Pierre-Antoine Dugué, Chenglong Yu, Allison Hodge, Ee Ming Wong, JiHoon Joo, Chol-Hee Jung, Daniel Schmidt, Enes Makalic, Daniel Buchanan, Gianluca Severi, Dallas English, John Hopper, Roger Milne, Graham Giles, Melissa Southey

2021-02-10

<h4>ABSTRACT</h4> Methylation marks of exposure to health risk factors may be useful markers of cancer risk as they might better c..

Biological Aging Measures Based on Blood DNA Methylation and Risk of Cancer: A Prospective Study

Pierre-Antoine Dugue, Julie K Bassett, Ee Ming Wong, JiHoon E Joo, Shuai Li, Chenglong Yu, Daniel F Schmidt, Enes Makalic, Nicole Wong Doo, Daniel D Buchanan, Allison M Hodge, Dallas R English, John L Hopper, Graham G Giles, Melissa C Southey, Roger L Milne

2021-02-01

BACKGROUND: We previously investigated the association between 5 "first-generation" measures of epigenetic aging and cancer risk i..

Genetic and environmental causes of variation in epigenetic aging across the lifespan

Shuai Li, Tuong L Nguyen, Ee Ming Wong, Pierre-Antoine Dugue, Gillian S Dite, Nicola J Armstrong, Jeffrey M Craig, Karen A Mather, Perminder S Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L Milne, Graham G Giles, Melissa C Southey, John L Hopper

2020-10-22

BACKGROUND: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ra..

Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms

Amedeo Gagliardi, Pierre-Antoine Dugue, Therese H Nost, Melissa C Southey, Daniel D Buchanan, Daniel F Schmidt, Enes Makalic, Allison M Hodge, Dallas R English, Nicole W Doo, John L Hopper, Gianluca Severi, Laura Baglietto, Alessio Naccarati, Sonia Tarallo, Luigia Pace, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote

2020-10-01

BACKGROUND: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic..

Overall lack of replication of associations between dietary intake of folate and vitamin B-12 and DNA methylation in peripheral blood

Pierre-Antoine Dugue, James A Chamberlain, Julie K Bassett, Allison M Hodge, Maree T Brinkman, JiHoon E Joo, Chol-Hee Jung, Ee Ming Wong, Enes Makalic, Daniel F Schmidt, John L Hopper, Daniel D Buchanan, Dallas R English, Roger L Milne, Melissa C Southey, Graham G Giles

2020-01-01

Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data

Pierre-Antoine Dugue, Rory Wilson, Benjamin Lehne, Harindra Jayasekara, Xiaochuan Wang, Chol-Hee Jung, JiHoon E Joo, Enes Makalic, Daniel F Schmidt, Laura Baglietto, Gianluca Severi, Christian Gieger, Karl-Heinz Ladwig, Annette Peters, Jaspal S Kooner, Melissa C Southey, Dallas R English, Melanie Waldenberger, John C Chambers, Graham G Giles

2019-12-02

DNA methylation may be one of the mechanisms by which alcohol consumption is associated with the risk of disease. We conducted a l..

DNA methylation-based biological age, genome-wide average DNA methylation, and conventional breast cancer risk factors

Minyuan Chen, Ee Ming Wong, Tuong L Nguyen, Gillian S Dite, Jennifer Stone, Pierre-Antoine Dugue, Graham G Giles, Melissa C Southey, Roger L Milne, John L Hopper, Shuai Li

2019-10-21

DNA methylation-based biological age (DNAm age), as well as genome-wide average DNA methylation, have been reported to predict bre..

Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures

Shuai Li, Pierre-Antoine Dugue, Laura Baglietto, Gianluca Severi, Ee Ming Wong, Tuong L Nguyen, Jennifer Stone, Dallas R English, Melissa C Southey, Graham G Giles, John L Hopper, Roger L Milne

2019-10-01

Age- and body mass index (BMI)-adjusted mammographic density is one of the strongest breast cancer risk factors. DNA methylation i..

Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility

Pierre-Antoine Dugue, Chol-Hee Jung, Jihoon E Joo, Xiaochuan Wang, Ee Ming Wong, Enes Makalic, Daniel F Schmidt, Laura Baglietto, Gianluca Severi, Melissa C Southey, Dallas R English, Graham G Giles, Roger L Milne

2019-09-26

We conducted a genome-wide association study of blood DNA methylation and smoking, attempted replication of previously discovered ..

Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis

Giovanni Fiorito, Cathal McCrory, Oliver Robinson, Cristian Carmeli, Carolina Ochoa Rosales, Yan Zhang, Elena Colicino, Pierre-Antoine Dugue, Fanny Artaud, Gareth J Mckay, Ayoung Jeong, Pashupati P Mishra, Therese H Nost, Vittorio Krogh, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Domenico Palli, Giuseppe Matullo, Simonetta Guarrera

2019-04-15

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of ..

Assessing the ProMCol classifier as a prognostic marker for non-metastatic colorectal cancer within the Melbourne Collaborative Cohort Study

Jihoon E Joo, Harindra Jayasekara, Ee Ming Wong, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Mark A Jenkins, John L Hopper, Dallas R English, Roger L Milne, Graham G Giles, Melissa C Southey, Daniel D Buchanan

2019-04-01

Physical Activity, Television Viewing Time, and DNA Methylation in Peripheral Blood

Eline H van Roekel, Pierre-Antoine Dugue, Chol-Hee Jung, Jihoon E Joo, Enes Makalic, Ee Ming Wong, Dallas R English, Melissa C Southey, Graham G Giles, Brigid M Lynch, Roger L Milne

2019-03-01

INTRODUCTION: Physical activity may affect health via DNA methylation. The epigenetic influences of sedentary behaviors such as te..

Physical activity and DNA methylation in peripheral blood: results from the Melbourne Collaborative Cohort Study

Eline H van Roekel, Pierre-Antoine Dugue, Dallas R English, JiHoon E Joo, Ee Ming Wong, Enes Makalic, Melissa C Southey, Graham G Giles, Roger L Milne, Brigid M Lynch

2018-10-01

Dietary intake of one-carbon metabolism nutrients and DNA methylation in peripheral blood

James A Chamberlain, Pierre-Antoine Dugue, Julie K Bassett, Allison M Hodge, Maree T Brinkman, JiHoon E Joo, Chol-Hee Jung, Enes Makalic, Daniel F Schmidt, John L Hopper, Daniel D Buchanan, Dallas R English, Melissa C Southey, Graham G Giles, Roger L Milne

2018-09-01

BACKGROUND: Folate and other one-carbon metabolism nutrients are essential to enable DNA methylation to occur, but the extent to w..

DNA methylation-based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

Pierre-Antoine Dugue, Julie K Bassett, JiHoon E Joo, Chol-Hee Jung, Ee Ming Wong, Margarita Moreno-Betancur, Daniel Schmidt, Enes Makalic, Shuai Li, Gianluca Severi, Allison M Hodge, Daniel D Buchanan, Dallas R English, John L Hopper, Melissa C Southey, Graham G Giles, Roger L Milne

2018-04-15

The association between aging and cancer is complex. Recent studies have developed measures of biological aging based on DNA methy..

Novel associations between blood DNA methylation and body mass index in middle-aged and older adults

YM Geurts, P-A Dugue, JE Joo, E Makalic, C-H Jung, W Guan, S Nguyen, ML Grove, EM Wong, AM Hodge, JK Bassett, LM FitzGerald, H Tsimiklis, L Baglietto, G Severi, DF Schmidt, DD Buchanan, RJ MacInnis, JL Hopper, JS Pankow

2018-04-01

BACKGROUND/OBJECTIVES: There is increasing evidence of a relationship between blood DNA methylation and body mass index (BMI). We ..

Association of DNA Methylation-Based Biological Age With Health Risk Factors and Overall and Cause-Specific Mortality

Pierre-Antoine Dugue, Julie K Bassett, JiHoon E Joo, Laura Baglietto, Chol-Hee Jung, Ee Ming Wong, Giovanni Fiorito, Daniel Schmidt, Enes Makalic, Shuai Li, Margarita Moreno-Betancur, Daniel D Buchanan, Paolo Vineis, Dallas R English, John L Hopper, Gianluca Severi, Melissa C Southey, Graham G Giles, Roger L Milne

2018-03-01

Measures of biological age based on blood DNA methylation, referred to as age acceleration (AA), have been developed. We examined ..

Epigenetic supersimilarity of monozygotic twin pairs

Timothy E Van Baak, Cristian Coarfa, Pierre-Antoine Dugue, Giovanni Fiorito, Eleonora Laritsky, Maria S Baker, Noah J Kessler, Jianrong Dong, Jack D Duryea, Matt J Silver, Ayden Saffari, Andrew M Prentice, Sophie E Moore, Akram Ghantous, Michael N Routledge, Yun Yun Gong, Zdenko Herceg, Paolo Vineis, Gianluca Severi, John L Hopper

2018-01-09

BACKGROUND: Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic vari..