Stress-induced disease risk for pregnant mothers born small
Grant number: 1025426 | Funding period: 2012 - 2014
This proposal addresses the likelihood that mothers born small and exposed to stress during pregnancy will develop adverse physiological adaptations to pregnancy, slowing placental and fetal growth, programming intergenerational disease and compromising maternal health later in life. The outcomes from our human and rat studies will enable development of diagnostic tests to identify pregnancies at greater risk and lead to therapies to reduce adverse intergenerational and long-term health effects.
Related publications (8)
Exercise alters cardiovascular and renal pregnancy adaptations in female rats born small on a high-fat diet
Dayana Mahizir, Jessica F Briffa, Kristina Anevska, Glenn D Wadley, Karen M Moritz, Mary E Wlodek
Intrauterine growth restriction programs adult cardiorenal disease, which may be exacerbated by pregnancy and obesity. Importantly..
Exercise improves metabolic function and alters the microbiome in rats with gestational diabetes
Dayana Mahizir, Jessica F Briffa, Jennifer L Wood, Kristina Anevska, Elisa L Hill-Yardin, Andrew J Jefferies, Sogand Gravina, Gisella Mazzarino, Ashley E Franks, Karen M Moritz, Glenn D Wadley, Mary E Wlodek
Gestational diabetes mellitus (GDM) is a common pregnancy complication, particularly prevalent in obese women. Importantly, exerci..
Treadmill Exercise before and during Pregnancy Improves Bone Deficits in Pregnant Growth Restricted Rats without the Exacerbated Effects of High Fat Diet
Kristina Anevska, Dayana Mahizir, Jessica E Briffa, Andrew J Jefferies, John D Wark, Brian L Grills, Rhys D Brady, Stuart J McDonald, Mary E Wlodek, Tania Romano
Growth restriction programs adult bone deficits and increases the risk of obesity, which may be exacerbated during pregnancy. We a..
The transgenerational effect of maternal and paternal F1 low birth weight on bone health of second and third generation offspring
K Anevska, JD Wark, ME Wlodek, T Romano
Low birth weight programs diseases in adulthood, including adverse bone health. These diseases can have intergenerational and tran..
Maternal stress does not exacerbate long-term bone deficits in female rats born growth restricted, with differential effects on offspring bone health
Kristina Anevska, Jean N Cheong, John D Wark, Mary E Wlodek, Tania Romano
Females born growth restricted have poor adult bone health. Stress exposure during pregnancy increases risk of pregnancy complicat..
Maternal growth restriction and stress exposure in rats differentially alters expression of components of the placental glucocorticoid barrier and nutrient transporters
Jessica F Briffa, Sogand S Hosseini, Tran Melanie, Karen M Moritz, James SM Cuffe, Mary E Wlodek
The placenta plays a major role in the development of fetal growth restriction, which affects 10% of pregnancies and contributes t..
Sex-Specific Metabolic Outcomes in Offspring of Female Rats Born Small or Exposed to Stress During Pregnancy
Jean N Cheong, James SM Cuffe, Andrew J Jefferies, Kristina Anevska, Karen M Moritz, Mary E Wlodek
Low birth weight increases adult metabolic disease risk in both the first (F1) and second (F2) generation. Physiological stress du..
Adrenal, metabolic and cardio-renal dysfunction develops after pregnancy in rats born small or stressed by physiological measurements during pregnancy
Jean N Cheong, James SM Cuffe, Andrew J Jefferies, Karen M Moritz, Mary E Wlodek
KEY POINTS: Women born small are at an increased risk of developing pregnancy complications. Stress may further increase a woman's..