The role of AGE/RAGE in liver disease

Grant number: 1029990 | Funding period: 2012 - 2014

Completed

Abstract

Cirrhosis of the liver due to non-alcoholic fatty liver disease, chronic hepatitis and other liver diseases is now a major cause of illness and death in Australia. This project will examine how advanced glycation end products (AGEs), compounds formed in the body and also derived from our diet, contributes to the progression of liver scarring in these diseases. We will study whether drugs targeting these compounds can be used to reduce liver scarring and prevent the development of cirrhosis.

Related publications (6)

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Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products

Dinali H Fernando, Josephine M Forbes, Peter W Angus, Chandana B Herath

2019-10-02

Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population and is now a major cause of liver disease-rela..

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Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD

Eveline Bruinstroop, Rinkoo Dalan, Yang Cao, Yong Mong Bee, Kurumbian Chandran, Li Wei Cho, Shui Boon Soh, Eng Kiong Teo, Sue-Anne Toh, Melvin Khee Shing Leow, Rohit A Sinha, Suresh Anand Sadananthan, Navin Michael, Heather M Stapleton, Christopher Leung, Peter W Angus, Sheila K Patel, Louise M Burrell, Su Chi Lim, Chee Fang Sum

2018-07-01

CONTEXT: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in patients with type 2 diabetes mellitus (T2DM) and associa..

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Glycation: a new hope in targeting hepatocellular carcinoma?

Christopher Leung, Peter W Angus, Josephine M Forbes

2017-12-01

Hepatocellular carcinoma (HCC) is the second most common cause of cancer mortality worldwide and is the most rapidly growing indic..

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The role of the gut microbiota in NAFLD

Christopher Leung, Leni Rivera, John B Furness, Peter W Angus

2016-07-01

NAFLD is now the most common cause of liver disease in Western countries. This Review explores the links between NAFLD, the metabo..

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Role of the Alternate RAS in Liver Disease and the GI Tract

CB Herath, KY Mak, PW Angus

2015-04-22

Recent findings suggesting antifibrotic and vasodilatory functions of the alternate arm of the renin-angiotensin system (RAS) in l..

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Damage to enteric neurons occurs in mice that develop fatty liver disease but not diabetes in response to a high-fat diet

LR Rivera, C Leung, RV Pustovit, BL Hunne, S Andrikopoulos, C Herath, A Testro, PW Angus, JB Furness

2014-08-01

BACKGROUND: Disorders of gastrointestinal functions that are controlled by enteric neurons commonly accompany fatty liver disease...