Characterization of a novel bacterial secretion system
Grant number: 1027812 | Funding period: 2012 - 2014
In this study we will characterize a novel bacterial secretion system that we have discovered. This system mediates the secretion of proteins from the bacterial cell and their attachment to the cell surface. This system is essential for the virulence of a bacterium associated with severe gum disease. The chacterization of this system may offer opportunities for the development of new treatments to target this disease.
Related publications (2)
Porphyromonas gingivalis Type IX Secretion Substrates Are Cleaved and Modified by a Sortase-Like Mechanism
Dhana G Gorasia, Paul D Veith, Dina Chen, Christine A Seers, Helen A Mitchell, Yu-Yen Chen, Michelle D Glew, Stuart G Dashper, Eric C Reynolds
The type IX secretion system (T9SS) of Porphyromonas gingivalis secretes proteins possessing a conserved C-terminal domain (CTD) t..
Protein Substrates of a Novel Secretion System Are Numerous in the Bacteroidetes Phylum and Have in Common a Cleavable C-Terminal Secretion Signal, Extensive Post-Translational Modification, and Cell-Surface Attachment
Paul D Veith, Nor A Nor Muhammad, Stuart G Dashper, Vladimir A Likic, Dhana G Gorasia, Dina Chen, Samantha J Byrne, Deanne V Catmull, Eric C Reynolds
The secretion of certain proteins in Porphyromonas gingivalis is dependent on a C-terminal domain (CTD). After secretion, the CTD ..