Immunity to malaria in pregnancy
Grant number: 1024441 | Funding period: 2012 - 2015
Increasing malaria control efforts may lead to lack of exposure needed to develop immunity. We will use plasma samples from Africa, PNG and Asia, and measures of immunity we have developed, to discover (1) which are the most important protective immune responses and (2) how are these affected by changing exposure or new drugs. Overall, we hope to identify markers of protective immunity that can be used to identify women at most risk of malaria in pregnancy and its complications
Related publications (8)
Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays
Mirja Hommel, Jo-Anne Chan, Alexandra J Umbers, Christine Langer, Stephen J Rogerson, Joseph D Smith, James G Beeson
BACKGROUND: Malaria in pregnancy is a major cause of poor maternal and infant health, and is associated with the sequestration of ..
Association between malaria immunity and pregnancy outcomes among Malawian pregnant women receiving nutrient supplementation
Upeksha P Chandrasiri, Freya JI Fowkes, James G Beeson, Jack S Richards, Steve Kamiza, Kenneth Maleta, Per Ashorn, Stephen J Rogerson
BACKGROUND: Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low bir..
Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
Michael F Duffy, Rintis Noviyanti, Takafumi Tsuboi, Zhi-Ping Feng, Leily Trianty, Boni F Sebayang, Eizo Takashima, Fransisca Sumardy, Daniel A Lampah, Louise Turner, Thomas Lavstsen, Freya JI Fowkes, Peter Siba, Stephen J Rogerson, Thor G Theander, Jutta Marfurt, Ric N Price, Nicholas M Anstey, Graham V Brown, Anthony T Papenfuss
BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic..
Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission
Andrew Teo, Wina Hasang, Louise M Randall, Holger W Unger, Peter M Siba, Ivo Mueller, Graham V Brown, Stephen J Rogerson
BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic..
A Robust Phagocytosis Assay to Evaluate the Opsonic Activity of Antibodies against Plasmodium falciparum-Infected Erythrocytes
Andrew Teo, Wina Hasang, Philippe Boeuf, Stephen Rogerson
Infection with Plasmodium falciparum parasites causes the majority of malaria-related morbidity and mortality. Constant exposure t..
Evaluating IgG Antibody to Variant Surface Antigens Expressed on Plasmodium falciparum Infected Erythrocytes Using Flow Cytometry
Andrew Teo, Wina Hasang, Stephen Rogerson
Constant exposure to Plasmodium falciparum leads to acquisition of malarial antibodies that can protect against the clinical conse..
Decreasing Malaria Prevalence and Its Potential Consequences for Immunity in Pregnant Women
Andrew Teo, Wina Hasang, Louise M Randall, Gaoqian Feng, Lauren Bell, Holger Unger, Christine Langer, James G Beeson, Peter M Siba, Ivo Mueller, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson
BACKGROUND: As malaria control is intensified, pregnant women may be less exposed to malaria, thus affecting the acquisition of pr..
Low Antibody Levels to Pregnancy-specific Malaria Antigens and Heightened Cytokine Responses Associated With Severe Malaria in Pregnancy
Upeksha P Chandrasiri, Louise M Randall, Alfarazdeg A Saad, Ahmed M Bashir, Stephen J Rogerson, Ishag Adam
BACKGROUND: Pregnant women living in unstable malaria transmission settings may develop severe malaria (SM). The pathogenesis of ..