Characterising the harmful effects of urokinase in asthma
Grant number: 1022048 | Funding period: 2012 - 2015
The scarring of airway tissue in asthma increases the difficulty of breathing. There is no effective treatment for airway scarring in severe asthma. This study looks at how proteins involved in dissolving blood clots influence wound healing and scarring in the airways. A better understanding of airway tissue scarring will lead to possible treatments for more serious forms of asthma which remain a major health and economic burden to our community.
Related publications (5)
Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity
Michael Schuliga, Jade Jaffar, Asres Berhan, Shenna Langenbach, Trudi Harris, David Waters, Peter VS Lee, Christopher Grainge, Glen Westall, Darryl Knight, Alastair G Stewart
In lung injury and disease, including idiopathic pulmonary fibrosis (IPF), extravascular factor X is converted into factor Xa (FXa..
The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF
Michael Schuliga, Jade Jaffar, Trudi Harris, Darryl A Knight, Glen Westall, Alastair G Stewart
The role of urokinase plasminogen activator (uPA) in idiopathic pulmonary fibrosis (IPF) remains unclear. uPA-generated plasmin ha..
The Coagulant Factor Xa Induces Protease-Activated Receptor-1 and Annexin A2-Dependent Airway Smooth Muscle Cytokine Production and Cell Proliferation
Michael Schuliga, Simon G Royce, Shenna Langenbach, Asres Berhan, Trudi Harris, Christine R Keenan, Alastair G Stewart
During asthma exacerbation, plasma circulating coagulant factor X (FX) enters the inflamed airways and is activated (FXa). FXa may..
Plasminogen-stimulated airway smooth muscle cell proliferation is mediated by urokinase and annexin A2, involving plasmin-activated cell signalling
AG Stewart, YC Xia, T Harris, S Royce, JA Hamilton, M Schuliga
BACKGROUND AND PURPOSE: The conversion of plasminogen into plasmin by interstitial urokinase plasminogen activator (uPA) is potent..
Plasminogen-Stimulated Inflammatory Cytokine Production by Airway Smooth Muscle Cells Is Regulated by Annexin A2
Michael Schuliga, Shenna Langenbach, Yuxiu C Xia, Chengxue Qin, Josephine SL Mok, Trudi Harris, Graham A Mackay, Robert L Medcalf, Alastair G Stewart
Plasminogen has a role in airway inflammation. Airway smooth muscle (ASM) cells cleave plasminogen into plasmin, a protease with p..