How influenza virus infects immune cells

Grant number: 1027545 | Funding period: 2012 - 2014

Completed

Abstract

Influenza virus is a leading cause of respiratory infection and death worldwide. Infection of humans is initiated when the virus contacts cells lining the respiratory tract. Infection of epithelial cells leads to virus amplification whereas infection of immune cells results in virus destruction. Despite extensive research efforts, it is not clear how the virus infects these cells. This project aims to identify receptors on human cells used by influenza virus to attach to and infect immune cells.

Related publications (8)

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DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans

Leah Gillespie, Kathleen Gerstenberg, Fernanda Ana-Sosa-Batiz, Matthew S Parsons, Rubaiyea Farrukee, Mark Krabbe, Kirsten Spann, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

2016-09-01

UNLABELLED: It is well established that glycosaminoglycans (GAGs) function as attachment factors for human metapneumovirus (HMPV),..

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Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN

Leah Gillespie, Paula Roosendahl, Wy Ching Ng, Andrew G Brooks, Patrick C Reading, Sarah L Londrigan

2016-01-14

The ubiquitous presence of cell-surface sialic acid (SIA) has complicated efforts to identify specific transmembrane glycoproteins..

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The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus

Wy Ching Ng, Sarah L Londrigan, Najla Nasr, Anthony L Cunningham, Stuart Turville, Andrew G Brooks, Patrick C Reading

2016-01-01

UNLABELLED: It is well established that influenza A virus (IAV) attachment to and infection of epithelial cells is dependent on si..

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Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle

Sarah L Londrigan, Kirsty R Short, Joel Ma, Leah Gillespie, Steven P Rockman, Andrew G Brooks, Patrick C Reading

2015-12-01

UNLABELLED: Airway epithelial cells are susceptible to infection with seasonal influenza A viruses (IAV), resulting in productive ..

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Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection

Michelle D Tate, Emma R Job, Yi-Mo Deng, Vithiagaran Gunalan, Sebastian Maurer-Stroh, Patrick C Reading

2014-03-01

Seasonal influenza A viruses (IAV) originate from pandemic IAV and have undergone changes in antigenic structure, including additi..

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The Macrophage Galactose-Type Lectin Can Function as an Attachment and Entry Receptor for Influenza Virus

Wy Ching Ng, Stella Liong, Michelle D Tate, Tatsuro Irimura, Kaori Denda-Nagai, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

2014-02-01

Specific protein receptors that mediate internalization and entry of influenza A virus (IAV) have not been identified for any cell..

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The fate of influenza A virus after infection of human macrophages and dendritic cells

Kirsty R Short, Andrew G Brooks, Patrick C Reading, Sarah L Londrigan

2012-11-01

Airway macrophages (MΦ) and dendritic cells (DC) are important components of the innate host defence. Historically, these immune c..

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Cell-surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus

Sarah L Londrigan, Michelle D Tate, Andrew G Brooks, Patrick C Reading

2012-07-01

Airway MΦ and DCs are important components of innate host defense and can play a critical role in limiting the severity of influen..

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